Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NDUFA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NDUFA2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with Als, Ms. Connected to 13 entities in the SciDEX knowledge graph.
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| Gene Symbol | NDUFA2 |
| Chromosome | 8q12.3 |
| Protein Type | Gene |
| Function | NDUFA2 (also known as B8) is a small accessory subunit of NADH dehydrogenase (Complex I). |
| Ensembl ID | ENSG00000177257 |
| GeneCards | NDUFA2 |
| Human Protein Atlas | NDUFA2 |
| Associated Diseases | neurodegeneration |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NDUFA2["NDUFA2"]
Als{"Als"}
NDUFA2 -->|"regulates"| Als
Ms{"Ms"}
NDUFA2 -->|"regulates"| Ms
NDUFS6["NDUFS6"]
NDUFA2 -->|"associated with"| NDUFS6
NDUFA1["NDUFA1"]
NDUFA2 -->|"associated with"| NDUFA1
CBL["CBL"]
NDUFA2 -->|"associated with"| CBL
PDGFRB["PDGFRB"]
NDUFA2 -->|"associated with"| PDGFRB
HSP90AB1["HSP90AB1"]
NDUFA2 -->|"associated with"| HSP90AB1
CRKL["CRKL"]
NDUFA2 -->|"associated with"| CRKL
DOCK1["DOCK1"]
NDUFA2 -->|"associated with"| DOCK1
NDUFA12["NDUFA12"]
NDUFA2 -->|"associated with"| NDUFA12
YWHAH["YWHAH"]
NDUFA2 -->|"associated with"| YWHAH
NDUFS5["NDUFS5"]
NDUFA2 -->|"associated with"| NDUFS5
style NDUFA2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| NDUFS6 | associated_with | gene | 0.60 |
| NDUFA1 | associated_with | gene | 0.60 |
| CBL | associated_with | gene | 0.60 |
| PDGFRB | associated_with | gene | 0.60 |
| HSP90AB1 | associated_with | gene | 0.60 |
| CRKL | associated_with | gene | 0.60 |
| DOCK1 | associated_with | gene | 0.60 |
| NDUFA12 | associated_with | gene | 0.60 |
| YWHAH | associated_with | gene | 0.60 |
| NDUFS5 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NDUFA2 in their description or question text
No additional research found