gene

CRKL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRKL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

6Outgoing

6Incoming

0Experiments

0Debates

Summary

CRKL (CRK-like proto-oncogene) is an adaptor protein involved in RAS/JNK signaling, BCR-ABL signaling, and cellular transformation

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🧬 Gene Info

Gene Symbol	CRKL
Aliases	CRK-like proto-oncogene
Chromosome	22q11.21
Protein Type	Adaptor Protein
Function	is a gene encoding an adaptor protein that plays critical roles in intracellular signal transduction.
Subcellular Localization	Cytoplasm, plasma membrane
Molecular Weight	34 kDa
Amino Acids	303 aa
Exons	12
Pathways	MAPK pathway
UniProt ID	P46109
NCBI Gene ID	1399
GeneCards	CRKL
Human Protein Atlas	CRKL
Associated Diseases	neurodegeneration
KG Connections	12 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CRKL — AlphaFold P46109 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CRKL Gene

gene · 1383 words

→

CRKL Protein

protein · 628 words

→

Pathway Diagram

graph TD
    CRKL["CRKL"]
    Als{"Als"}
    CRKL -->|"regulates"| Als
    Ms{"Ms"}
    CRKL -->|"regulates"| Ms
    DOCK1["DOCK1"]
    CRKL -->|"associated with"| DOCK1
    NDUFA12["NDUFA12"]
    CRKL -->|"associated with"| NDUFA12
    YWHAH["YWHAH"]
    CRKL -->|"associated with"| YWHAH
    NDUFS5["NDUFS5"]
    CRKL -->|"associated with"| NDUFS5
    neurodegeneration["neurodegeneration"]
    CRKL -->|"implicated in"| neurodegeneration
    NDUFA2["NDUFA2"]
    NDUFA2 -->|"associated with"| CRKL
    NDUFS6["NDUFS6"]
    NDUFS6 -->|"associated with"| CRKL
    NDUFA1["NDUFA1"]
    NDUFA1 -->|"associated with"| CRKL
    CBL["CBL"]
    CBL -->|"associated with"| CRKL
    PDGFRB["PDGFRB"]
    PDGFRB -->|"associated with"| CRKL
    HSP90AB1["HSP90AB1"]
    HSP90AB1 -->|"associated with"| CRKL
    style CRKL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
DOCK1	associated_with	gene	0.60
NDUFA12	associated_with	gene	0.60
YWHAH	associated_with	gene	0.60
NDUFS5	associated_with	gene	0.60

Incoming (6)

Source	Relation	Type	Str
NDUFA2	associated_with	gene	0.60
NDUFS6	associated_with	gene	0.60
NDUFA1	associated_with	gene	0.60
CBL	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
HSP90AB1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CRKL in their description or question text

No additional research found