gene

NDUFA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

0Hypotheses

0Analyses

16Outgoing

16Incoming

0Experiments

0Debates

Summary

NDUFA1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, causes. Associated with Als, Ms, Neurodegeneration. Connected to 21 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NDUFA1
Protein Type	Gene
Function	NDUFA1 encodes a core subunit of NADH dehydrogenase (Complex I), the largest enzyme of the mitochondrial respiratory chain.
Pathways	Nf-Κb
Ensembl ID	ENSG00000125351
GeneCards	NDUFA1
Human Protein Atlas	NDUFA1
Associated Diseases	neurodegeneration
Interactions	CREB1, NEURODEGENERATION, ROS
KG Connections	32 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NDUFA1["NDUFA1"]
    Als{"Als"}
    NDUFA1 -->|"regulates"| Als
    Ms{"Ms"}
    NDUFA1 -->|"regulates"| Ms
    CBL["CBL"]
    NDUFA1 -->|"associated with"| CBL
    PDGFRB["PDGFRB"]
    NDUFA1 -->|"associated with"| PDGFRB
    HSP90AB1["HSP90AB1"]
    NDUFA1 -->|"associated with"| HSP90AB1
    CRKL["CRKL"]
    NDUFA1 -->|"associated with"| CRKL
    DOCK1["DOCK1"]
    NDUFA1 -->|"associated with"| DOCK1
    NDUFA12["NDUFA12"]
    NDUFA1 -->|"associated with"| NDUFA12
    YWHAH["YWHAH"]
    NDUFA1 -->|"associated with"| YWHAH
    NDUFS5["NDUFS5"]
    NDUFA1 -->|"associated with"| NDUFS5
    neurodegeneration["neurodegeneration"]
    NDUFA1 -->|"implicated in"| neurodegeneration
    NDUFA2["NDUFA2"]
    NDUFA2 -->|"associated with"| NDUFA1
    NDUFS6["NDUFS6"]
    NDUFS6 -->|"associated with"| NDUFA1
    style NDUFA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
developmental defects	downregulates	phenotype	0.82
Alzheimer	regulates	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	regulates	disease	0.65
CRKL	associated_with	gene	0.60
DOCK1	associated_with	gene	0.60
NDUFA12	associated_with	gene	0.60
YWHAH	associated_with	gene	0.60
NDUFS5	associated_with	gene	0.60
CBL	associated_with	gene	0.60
Oxidative Phosphorylation	activates	pathway	0.60
PDGFRB	associated_with	gene	0.60
HSP90AB1	associated_with	gene	0.60
ABCA7	regulates	gene	0.60
Nf-Κb	regulates	pathway	0.60

Incoming (16)

Source	Relation	Type	Str
TYK2	regulates	gene	0.60
ABCA7	regulates	gene	0.60
GENES	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
INOS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
CREB1	activates	gene	0.60
NDUFA2	associated_with	gene	0.60
NDUFS6	associated_with	gene	0.60
NAD	causes	gene	0.60
ROS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	causes	gene	0.60
MITOCHONDRIA	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDUFA1 in their description or question text

No additional research found