gene

COX8A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COX8A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

6Outgoing

5Incoming

0Experiments

0Debates

Summary

COX8A (Cytochrome c Oxidase Subunit 8A): Nuclear-encoded mitochondrial protein essential for Complex IV assembly and neuronal energy metabolism, implicated in Alzheimer's and Parkinson's disease

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🧬 Gene Info

Gene Symbol	COX8A
Full Name	Cytochrome c Oxidase Subunit 8A
Chromosome	11q13.1
Function	is a nuclear-encoded mitochondrial protein that serves as a structural subunit of cytochrome c oxidase (Complex IV) of the electron transport chain.
Molecular Weight	7.8 kDa
Amino Acids	69 aa
UniProt ID	[P10176](https://www.uniprot.org/uniprot/P10176)
Ensembl ID	ENSG00000160789
GeneCards	COX8A
Human Protein Atlas	COX8A
Assembly factor	COX8A is required for proper Complex IV assembly and stability
Dimer formation	COX8A participates in Complex IV dimer formation, which is important for cristae organization
Proton channel	Contributes to the proton exit channel of the enzyme
High expression	Heart, skeletal muscle, brain (especially cortex and hippocampus)
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	COX15, COX4I1, COX7A1, NDUFA12, NDUFA5, NDUFS1
KG Connections	11 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

COX8A Gene

gene · 2163 words

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Pathway Diagram

flowchart TD
    N0["COX8A"]
    N1["NDUFA12"]
    N0 -->|"co expressed with"| N1
    N2["NDUFA5"]
    N0 -->|"co expressed with"| N2
    N3["COX4I1"]
    N3 -->|"co expressed with"| N0
    N4["COX7A1"]
    N4 -->|"co expressed with"| N0
    N5["neurodegeneration"]
    N0 -->|"implicated in"| N5

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene

Outgoing (6)

Target	Relation	Type	Str
NDUFA12	inhibits	gene	0.60
NDUFA5	inhibits	gene	0.60
NDUFS1	inhibits	gene	0.60
NDUFS4	inhibits	gene	0.60
NDUFA12	co_expressed_with	gene	0.50
NDUFA5	co_expressed_with	gene	0.50

Incoming (5)

Source	Relation	Type	Str
COX15	inhibits	gene	0.60
COX4I1	inhibits	gene	0.60
COX7A1	inhibits	gene	0.60
COX4I1	co_expressed_with	gene	0.50
COX7A1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COX8A in their description or question text

No additional research found