gene

NDUFA5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFA5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

6Outgoing

9Incoming

0Experiments

0Debates

Summary

Page for NDUFA5 — NADH:ubiquinone Oxidoreductase Subunit A5

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🧬 Gene Info

Gene Symbol	NDUFA5
Full Name	NADH:ubiquinone Oxidoreductase Subunit A5
Chromosome	7q31.32
Function	encodes a 116-amino acid protein that is part of the Q module of mitochondrial Complex I[@koopman2013].
Primary Expression	Ubiquitous (high in brain, heart, muscle)
Molecular Weight	13kDa
Amino Acids	116 aa
UniProt ID	P06540
NCBI Gene ID	4698
Ensembl ID	ENSG00000167863
GeneCards	NDUFA5
Human Protein Atlas	NDUFA5
Associated Diseases	Leigh syndrome, mitochondrial complex I deficiency
Interactions	COX15, COX4I1, COX7A1, COX8A, NDUFA12, NDUFS1
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NDUFA5 — AlphaFold P06540 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NDUFA5 — NADH:ubiquinone Oxidoreductase Subunit A5

gene · 520 words

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Pathway Diagram

graph TD
    NDUFA5["NDUFA5"]
    neurodegeneration["neurodegeneration"]
    NDUFA5 -->|"implicated_in"| neurodegeneration
    style NDUFA5 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFA5	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
NDUFS1	inhibits	gene	0.60
NDUFS4	inhibits	gene	0.60
NDUFS1	co_expressed_with	gene	0.50
NDUFS4	co_expressed_with	gene	0.50

Incoming (9)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFA5	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
COX15	inhibits	gene	0.60
COX4I1	inhibits	gene	0.60
COX7A1	inhibits	gene	0.60
COX8A	inhibits	gene	0.60
NDUFA12	inhibits	gene	0.60
COX8A	co_expressed_with	gene	0.50
NDUFA12	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDUFA5 in their description or question text

No additional research found