gene 1,431 words KG: NAGLU
Contents

NAGLU — Alpha-N-Acetylglucosaminidase

🧬 Gene Info
Gene SymbolNAGLU
Full NameAlpha-N-Acetylglucosaminidase
Protein TypeEnzyme
FunctionNAGLU encodes alpha-N-acetylglucosaminidase, a lysosomal enzyme that catalyzes the N-acetylglucosaminide hydrolysis in heparan sulfate glycosaminoglycans.
Molecular Weight73.9 kDa
Amino Acids739 aa
Ensembl IDENSG00000108784
GeneCardsNAGLU
Human Protein AtlasNAGLU
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsACTB, ATG12, ATG5, ATG7, BECN1, CTSD
KG Connections20 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (3)

Lysosomal Positioning Dynamics Modulation
Score: 0.69
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62

Related Analyses (5)

GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

ACTB activates NAGLU
ATG12 activates NAGLU
ATG5 activates NAGLU
ATG7 activates NAGLU
BECN1 activates NAGLU
CTSD activates NAGLU
CTSL activates NAGLU
LAMP1 activates NAGLU
LAMP2 activates NAGLU
LC3 activates NAGLU

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