Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | KCNK3 |
| Full Name | Potassium Two Pore Domain Channel Subfamily K Member 3 |
| Aliases | TASK-1, TASK-1 Potassium Channel |
| Chromosome | 2p23.3 |
| Primary Expression | seizure-prone brain regions |
| Molecular Weight | 45 kDa |
| Pathways | BMP signaling |
| UniProt ID | O60654 |
| NCBI Gene ID | 3777 |
| Ensembl ID | ENSG00000171303 |
| OMIM | 603217 |
| GeneCards | KCNK3 |
| Human Protein Atlas | KCNK3 |
| pH sensitivity | Activated by alkaline extracellular pH, inhibited by acidosis (pH 5.5-7.0)[@ma2022] |
| Volatile anesthetic sensitivity | Inhibited by halogenated anesthetics (isoflurane, sevoflurane)[@patel1999] |
| Associated Diseases | pulmonary arterial hypertension |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNK3["KCNK3"]
pulmonary_arterial_hypertension{"pulmonary arterial hypertension"}
KCNK3 -->|"associated with"| pulmonary_arterial_hypertension
BMP_signaling(["BMP signaling"])
KCNK3 -->|"regulates"| BMP_signaling
pulmonary_vascular_smooth_muscle_cell["pulmonary vascular smooth muscle cell"]
KCNK3 -->|"expressed in"| pulmonary_vascular_smooth_muscle_cell
KCNK3 -->|"causes"| pulmonary_arterial_hypertension
proliferation["proliferation"]
KCNK3 -->|"inhibits"| proliferation
PUM1["PUM1"]
KCNK3 -->|"regulates"| PUM1
apoptosis["apoptosis"]
KCNK3 -->|"inhibits"| apoptosis
KCNK5["KCNK5"]
KCNK3 -->|"associated with"| KCNK5
Hypertension{"Hypertension"}
KCNK3 -->|"activates"| Hypertension
Heart_Failure{"Heart Failure"}
KCNK3 -->|"activates"| Heart_Failure
Als{"Als"}
KCNK3 -->|"activates"| Als
ALS{"ALS"}
KCNK3 -->|"activates"| ALS
PUM1 -->|"downregulates"| KCNK3
KCNK2["KCNK2"]
KCNK2 -->|"regulates"| KCNK3
KCNK1["KCNK1"]
KCNK1 -->|"regulates"| KCNK3
PAH["PAH"]
PAH -->|"regulates"| KCNK3
KCNK6["KCNK6"]
KCNK6 -->|"regulates"| KCNK3
AND["AND"]
AND -->|"regulates"| KCNK3
style KCNK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| pulmonary arterial hypertension | causes | disease | 0.80 |
| BMP signaling | regulates | pathway | 0.80 |
| pulmonary vascular smooth muscle cell | expressed_in | cell_type | 0.80 |
| pulmonary arterial hypertension | associated_with | disease | 0.80 |
| proliferation | inhibits | biological_process | 0.80 |
| PUM1 | regulates | gene | 0.80 |
| KCNK5 | associated_with | gene | 0.70 |
| Hypertension | activates | disease | 0.65 |
| Heart Failure | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| KCNK2 | regulates | gene | 0.60 |
| KCNK1 | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| KCNK6 | regulates | gene | 0.60 |
| PAH | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KCNK3 in their description or question text
No additional research found