Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KCNK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Als, Fibrosis. Connected to 20 entities in the SciDEX knowledge graph.
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| Gene Symbol | KCNK1 |
| Full Name | Potassium Two Pore Domain Channel Subfamily K Member 1 |
| Chromosome | 1q42.12 |
| Function | encodes the TWIK-1 potassium channel, a member of the two-pore domain (K2P) potassium channel family |
| Exons | 4 |
| Pathways | Interaction |
| UniProt ID | O00180 |
| NCBI Gene ID | 3775 |
| Ensembl ID | ENSG00000135750 |
| OMIM | 603457 |
| GeneCards | KCNK1 |
| Human Protein Atlas | KCNK1 |
| Associated Diseases | neurodegeneration |
| Interactions | AND, KCNK2 |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNK1["KCNK1"]
TWIK1["TWIK1"]
KCNK1 -->|"encodes"| TWIK1
Hypertension{"Hypertension"}
KCNK1 -->|"activates"| Hypertension
Heart_Failure{"Heart Failure"}
KCNK1 -->|"activates"| Heart_Failure
Als{"Als"}
KCNK1 -->|"activates"| Als
Fibrosis{"Fibrosis"}
KCNK1 -->|"inhibits"| Fibrosis
KCNK1 -->|"inhibits"| Als
ALS{"ALS"}
KCNK1 -->|"activates"| ALS
CELL_PROLIFERATION["CELL_PROLIFERATION"]
KCNK1 -->|"activates"| CELL_PROLIFERATION
KCNK3["KCNK3"]
KCNK1 -->|"regulates"| KCNK3
KCNK6["KCNK6"]
KCNK1 -->|"regulates"| KCNK6
PAH["PAH"]
KCNK1 -->|"regulates"| PAH
KCNK2["KCNK2"]
KCNK1 -->|"activates"| KCNK2
KCNK2 -->|"activates"| KCNK1
PAH -->|"regulates"| KCNK1
KCNK5["KCNK5"]
KCNK5 -->|"associated with"| KCNK1
KCNK6 -->|"associated with"| KCNK1
KCNK6 -->|"regulates"| KCNK1
AND["AND"]
AND -->|"activates"| KCNK1
KCNK3 -->|"regulates"| KCNK1
style KCNK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| TWIK1 | encodes | protein | 0.72 |
| ALS | activates | disease | 0.65 |
| Hypertension | activates | disease | 0.65 |
| Heart Failure | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Fibrosis | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| CELL_PROLIFERATION | activates | phenotype | 0.64 |
| KCNK3 | regulates | gene | 0.60 |
| KCNK6 | regulates | gene | 0.60 |
| KCNK2 | associated_with | gene | 0.60 |
| PAH | regulates | gene | 0.60 |
| KCNK2 | regulates | entity | 0.60 |
| KCNK2 | inhibits | entity | 0.60 |
| AND | activates | gene | 0.60 |
| KCNK2 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KCNK1 in their description or question text
No additional research found