gene

JNK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JNK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

0Hypotheses

0Analyses

31Outgoing

19Incoming

0Experiments

0Debates

Summary

JNK2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with ALS, Als. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	JNK2
Full Name	Mitogen-Activated Protein Kinase 9
Aliases	MAPK9
Chromosome	5q35.3
Protein Family	MAPK family (JKN/SAPK)
Molecular Weight	46 kDa
Amino Acids	424 aa
Pathways	MAPK, Mapk
UniProt ID	[P53779](https://www.uniprot.org/uniprot/P53779)
Ensembl ID	ENSG00000050748
GeneCards	JNK2
Human Protein Atlas	JNK2
JNK1 (MAPK8)	Ubiquitously expressed, ~46 kDa
JNK2 (MAPK9)	Ubiquitously expressed, ~46 kDa
JNK3 (MAPK10)	Neuron-specific, ~46 kDa
Associated Diseases	ALS, Ms
Interactions	BIP, C-JUN, Jnk, JNK1, JUN, MAP
KG Connections	50 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    JNK2["JNK2"]
    Als{"Als"}
    JNK2 -->|"activates"| Als
    ALS{"ALS"}
    JNK2 -->|"activates"| ALS
    Er_Stress(["Er Stress"])
    JNK2 -->|"activates"| Er_Stress
    JUN["JUN"]
    JNK2 -->|"activates"| JUN
    JNK1["JNK1"]
    JNK2 -->|"activates"| JNK1
    C_JUN["C-JUN"]
    JNK2 -->|"activates"| C_JUN
    BIP["BIP"]
    JNK2 -->|"activates"| BIP
    P38["P38"]
    JNK2 -->|"activates"| P38
    Chaperone(["Chaperone"])
    JNK2 -->|"activates"| Chaperone
    neurodegeneration["neurodegeneration"]
    JNK2 -->|"implicated in"| neurodegeneration
    JUN -->|"activates"| JNK2
    BIP -->|"activates"| JNK2
    JNK1 -->|"activates"| JNK2
    P38 -->|"activates"| JNK2
    C_JUN -->|"activates"| JNK2
    AND["AND"]
    AND -->|"activates"| JNK2
    style JNK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (31)

Target	Relation	Type	Str
ALS	activates	disease	0.65
Ms	associated_with	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Er Stress	activates	pathway	0.60
C-JUN	activates	gene	0.60
MAPK signaling	participates_in	pathway	0.60
ALS	associated_with	disease	0.60
JNK1	activates	gene	0.60
BIP	activates	gene	0.60
JUN	activates	gene	0.60
Chaperone	activates	pathway	0.60
MAP	activates	gene	0.60
P38	activates	gene	0.60
ER stress	activates	process	0.60
Jnk	activates	protein	0.60
Ubiquitin-Proteasome	therapeutic_target	pathway	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
C-JUN	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
Proteasome	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
MAP	co_expressed_with	protein	0.50

Incoming (19)

Source	Relation	Type	Str
JUN	activates	gene	0.60
BIP	activates	gene	0.60
JNK1	activates	gene	0.60
P38	activates	gene	0.60
JNK	expressed_in	gene	0.60
JNK3	expressed_in	gene	0.60
JNK1	expressed_in	gene	0.60
JUN	therapeutic_target	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
C-JUN	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.60
ATP	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
JNK1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning JNK2 in their description or question text

No additional research found