concept

IRON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections

10Hypotheses

2Analyses

30Outgoing

16Incoming

1Experiments

2Debates

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💡 Concept Info

Name	IRON
Related Diseases	CANCER, FERROPTOSIS, ROS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Iron Homeostasis Dysregulation in Neurodegeneration

mechanism · 3324 words

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Pathway Diagram

graph TD
    IRON["IRON"]
    IRON -->|"causes"| Ferroptosis["Ferroptosis"]
    IRON -->|"causes"| Phospholipid_Peroxidation["Phospholipid Peroxidation"]
    IRON -->|"upregulates"| Glycolysis["Glycolysis"]
    IRON -->|"mediates"| SNCA["SNCA"]
    IRON -->|"expressed in"| Brain["Brain"]
    Hemoglobin["Hemoglobin"] -->|"binds"| IRON
    Ferroportin["Ferroportin"] -->|"mediates"| IRON
    Ferritin["Ferritin"] -->|"binds"| IRON
    TFR1["TFR1"] -->|"mediates"| IRON
    TF["TF"] -->|"binds"| IRON
    Transferrin["Transferrin"] -->|"binds"| IRON
    Ferroptosis -->|"involved_in"| IRON
    ALOX15["ALOX15"] -->|"binds"| IRON

Outgoing (30)

Target	Relation	Type	Str
Oxidative Stress	causes	process	0.95
Ferroptosis	associated_with	process	0.95
Phospholipid Peroxidation	causes	process	0.95
Neurotransmitter Synthesis	involved_in	process	0.95
Mitochondrial Metabolism	involved_in	process	0.95
ferroptosis	drives	process	0.95
FTH1	binds	protein	0.95
Ferroptosis	causes	process	0.95
Ferroptosis	mediates	process	0.95
Myelination	involved_in	process	0.95
oxidative stress	mediates	process	0.95
hemoglobin	associated_with	protein	0.90
oxidative_stress	causes	phenotype	0.90
Microglia	associated_with	cell_type	0.90
FTMT	binds	protein	0.90
mitochondrial_dysfunction	causes	mechanism	0.90
SNCA	mediates	protein	0.85
Microglial Transcriptional State	modulates	phenotype	0.85
Glycolysis	upregulates	pathway	0.85
oxidized polyunsaturated fatty acid phospholipids	mediates	compound	0.85
lipid_peroxidation_products	causes	unknown	0.85
alzheimers	contributes_to	disease	0.85
Pro-inflammatory M1 Phenotype	associated_with	phenotype	0.85
Brain	expressed_in	cell_type	0.85
Neurodegeneration	causes	process	0.80
FERROPTOSIS	causes	phenotype	0.72
FERROPTOSIS	activates	phenotype	0.72
neuromelanin	modulates	process	0.70
lipid peroxidation	causes	mechanism	0.70
ROS	activates	phenotype	0.64

Incoming (16)

Source	Relation	Type	Str
Ferroptosis	associated_with	process	0.95
TF	binds	protein	0.95
siderophores	binds	compound	0.95
Ferroportin	mediates	protein	0.95
Hemoglobin	binds	protein	0.95
Ferritin	binds	protein	0.95
Lactoferrin	inhibits	protein	0.93
TFRC	binds	protein	0.90
TFRC	mediates	protein	0.90
Transferrin	binds	protein	0.90
34031600	traps	paper	0.90
40427409	catalyzes	paper	0.90
Transferrin	delivers	protein	0.90
Transferrin Receptor 2	transports	protein	0.80
CANCER	associated_with	disease	0.64
WNT	inhibits	gene	0.60

Targeting Hypotheses (10)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	View
Iron-driven lipid peroxidation and GPX4 failure create a fer	0.750	neurodegeneration	What mechanisms drive the self-amplifyin
SCFA-Producing Bacterial Depletion → Loss of Neuroprotective	0.700	neurodegeneration	What are the mechanisms by which gut mic
Labile iron pool expansion amplifies genotype-specific ALS f	0.664	neurodegeneration	Ferroptosis in ALS motor neuron vulnerab
Iron Chelation Therapy Targeting the Labile Iron Pool	0.640	neurodegeneration	Can ferroptosis inhibitors prevent BBB d

Hepcidin-Iron Set Point Hypothesis	0.577	endocrinology	Does TRT-induced erythrocytosis actually
H63D HFE Genotype-Guided Iron Chelation Therapy for Subset-S	0.550	-	Ferroptosis in ALS and motor neuron dise
Iron Dysregulation as Convergent Pathomechanism	0.455	neuroinflammation	Why do clinical manifestations overlap d
IRP2-Iron Axis Modulation to Reduce Ferroptotic Vulnerabilit	0.398	neurodegeneration	Microglial subtypes in neurodegeneration
Magnetofection-Enhanced IGFBPL1 Delivery via Superparamagnet	0.341	drug delivery	Can IGFBPL1 therapeutics effectively cro

Mentioning Analyses (2)

Scientific analyses that reference this entity

LRRK2 Risk Variants: Lysosomal Membrane Dynamics in DA vs Striatal Neurons

neurodegeneration | 2026-04-27 | 0 hypotheses

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.760

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat	in_vivo	post-cardiac-arrest neurodegen	0.768	0.72	Sprague-Dawley rat asphyxial c	abandoned	$48,000

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (2)

Multi-agent debates referencing this entity

How do GWAS-identified PD risk variants at the LRRK2 locus alter lysosomal membr

active · Rounds: 6 · Score: 0.89 · 2026-04-27

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

closed · Rounds: 4 · Score: 0.73 · 2026-04-25

Related Research

Hypotheses and analyses mentioning IRON in their description or question text

Hepcidin-Iron Set Point Hypothesis

Score: 0.577 · endocrinology · 2026-04-13

## Mechanistic Overview Hepcidin-Iron Set Point Hypothesis starts from the claim that modulating not yet specified withi

H63D HFE Genotype-Guided Iron Chelation Therapy for Subset-Selected ALS Patients

Score: 0.550 · unknown disease · 2026-04-16

## Mechanistic Overview H63D HFE Genotype-Guided Iron Chelation Therapy for Subset-Selected ALS Patients starts from the

Iron Dysregulation as Convergent Pathomechanism

Score: 0.455 · neuroinflammation · 2026-04-27

Multiple myelopathy etiologies converge through disruption of spinal cord iron homeostasis, leading to ferroptosis-media

IRP2-Iron Axis Modulation to Reduce Ferroptotic Vulnerability

Score: 0.398 · neurodegeneration · 2026-04-25

NOT RECOMMENDED. Contains a biochemical error that undermines the hypothesis. IREB2 binds to IRE sequences in the 5' UTR

Magnetofection-Enhanced IGFBPL1 Delivery via Superparamagnetic Iron Oxide Nanopa

Score: 0.341 · drug delivery · 2026-04-26

The molecular foundation of magnetofection-mediated IGFBPL1 delivery exploits superparamagnetic iron oxide nanoparticles