gene 1,198 words KG: HNRNPH1
Contents

HNRNPH1 Gene

🧬 Gene Info
Gene SymbolHNRNPH1
Full NameHeterogeneous Nuclear Ribonucleoprotein H1
AliasesHNRNPH1 gene
Chromosome5q31.3
FunctionRNA processing, alternative splicing, stress granule formation
Primary Expressionboth neurons and glial cells
Subcellular Localization**Nucleus**: Primary localization; concentrated in splicing speckles
Amino Acids449 aa
Exons10
PathwaysApoptosis, Autophagy, Innate Immunity
UniProt IDP31946
NCBI Gene ID3067
Ensembl IDENSG00000135638
GeneCardsHNRNPH1
Human Protein AtlasHNRNPH1
Associated Diseasesneurodegeneration
InteractionsAND, APOPTOSIS, AUTOPHAGY, BRCA1, BRCA2, CANCER
KG Connections30 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
PARP1 Inhibition Therapy
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Axonal RNA Transport Reconstitution
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
RNA Granule Nucleation Site Modulation
Score: 0.66
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ATR Gene
gene · KG edge: regulates
BRCA1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

SIRT6 regulates HNRNPH1
PARP1 activates HNRNPH1
HNRNPA1 activates HNRNPH1
MYC regulates HNRNPH1
DDX5 activates HNRNPH1
PIN1 regulates HNRNPH1
BRCA1 activates HNRNPH1
ATR regulates HNRNPH1
HNRNPH1 activates BRCA2
HNRNPH1 activates Ms

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