| Gene Symbol | DRD3 |
| Aliases | Dopamine Receptor D3 |
| Protein Type | Receptor |
| Function | The DR3 gene encodes a G protein-coupled receptor that The D3 dopamine receptor is a D2-like receptor that plays crucial roles in motor control, reward processing, and cognitive functions. |
| Subcellular Localization | </th><td>Plasma membrane, postsynaptic density</td></tr> |
| Pathways | NF-kB signaling, Nf-Κb, Oxidative Stress, oxidative stress response |
| Ensembl ID | ENSG00000151577 |
| GeneCards | DRD3 |
| Human Protein Atlas | DRD3 |
| Extracellular N-terminus | Contains glycosylation sites and contributes to ligand binding |
| Intracellular C-terminus | Contains phosphorylation sites for receptor regulation |
| Third intracellular loop | Important for G protein coupling |
| Orthosteric binding site | Located within the transmembrane bundle |
| Allosteric binding sites | Additional sites for modulator binding |
| Crystal structures available | 7R0F, 7RT8 |
| Associated Diseases | Als, Hepatitis, Inflammation, Lupus |
| Interactions | AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AND, IKK, INFLAMMATION |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!