concept

LOAD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LOAD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

4Hypotheses

1Analyses

1Outgoing

15Incoming

0Experiments

1Debates

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💡 Concept Info

Name	LOAD
Key Genes/Proteins	APOE, BAD, C1Q, C1QA, C1QC, DAG1

Pathway Diagram

graph TD
    LOAD[LOAD]
    LOAD -->|downregulates| SV2A[SV2A]
    decreased_lipApoE_LDLR_interac[decreased lipApoE-LDLR interactions] -.prevents.-> LOAD
    DAG1[DAG1] -->|implicated in| LOAD
    IGF1R[IGF1R] -->|implicated in| LOAD
    HSPG2[HSPG2] -->|implicated in| LOAD
    BAD[BAD] -->|implicated in| LOAD
    GBM[GBM] -->|implicated in| LOAD
    C1QA[C1QA] -->|implicated in| LOAD
    C1QC[C1QC] -->|implicated in| LOAD
    C1Q[C1Q] -->|implicated in| LOAD
    SPI1[SPI1] -->|implicated in| LOAD

Outgoing (1)

Target	Relation	Type	Str
SV2A	downregulates	protein	0.85

Incoming (15)

Source	Relation	Type	Str
T835M	associated_with	protein	0.72
EGFR	associated_with	gene	0.70
APOE	associated_with	gene	0.70
decreased lipApoE-LDLR interactions	prevents	process	0.70
DAG1	implicated_in	gene	0.50
IGF1R	implicated_in	gene	0.50
HSPG2	implicated_in	gene	0.50
BAD	implicated_in	gene	0.50
GBM	implicated_in	gene	0.50
C1QA	implicated_in	gene	0.50
C1QC	implicated_in	gene	0.50
C1Q	implicated_in	gene	0.50
SPI1	implicated_in	gene	0.50
ROS	implicated_in	gene	0.50
LDL	implicated_in	gene	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
H1: T-Type Calcium Channel–Driven Calcium Overload and Prote	0.730	neurodegeneration	Entorhinal cortex layer II vulnerability
MCU Calcium Overload via MFN2/GRP75/VDAC1 MAM Dysfunction	0.644	neurodegeneration	What upstream mechanisms cause TDP-43 to
Aβ-induced downregulation of circPDS5B derepresses TDP-43 mR	0.595	neurodegeneration	What mechanisms drive TDP-43 pathology s
TFEB Activation Clears Tau-Loaded Endolysosomal Compartments	0.560	neurodegeneration	Investigate prion-like spreading of tau

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.619

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract shows V1613M variant reduces amyloid plaques and damage in 5xFAD mi

closed · Rounds: 4 · Score: 0.60 · 2026-04-15

Related Research

Hypotheses and analyses mentioning LOAD in their description or question text

No additional research found