| Gene Symbol | COX15 |
| Full Name | Cytochrome C Oxidase Assembly Factor 15 |
| Chromosome | 10q24.2 |
| Function | COX15 plays a crucial role in the final steps of heme A synthesis |
| Primary Expression | all tissues with high energy demands: - Heart and skeletal muscle (highest expression) - Brain (neurons and glia) - Liver and kid |
| Subcellular Localization | </strong></td><td>Mitochondrial inner membrane</td></tr> [@ryan2022] |
| Molecular Weight | 42 kDa |
| UniProt ID | [Q7B433](https://www.uniprot.org/uniprot/Q7B433) |
| Ensembl ID | ENSG00000074981 |
| OMIM | 603646 |
| GeneCards | COX15 |
| Human Protein Atlas | COX15 |
| N-terminal Transmembrane Helices | 3-4 predicted transmembrane domains anchoring the protein to the inner membrane |
| Catalytic Domain | Faces the mitochondrial matrix and contains the active site for heme A biosynthesis |
| Heme Binding Site | Contains conserved cysteine residues for heme coordination |
| Associated Diseases | neurodegeneration |
| Interactions | ATP, COX4I1, COX7A1, COX8A, NDUFA12, NDUFA5 |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!