Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Microbiome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Indole-3-Lactic Acid | associated_with | compound | 0.95 |
| Indole-3-lactic acid | associated_with | compound | 0.95 |
| Circadian Rhythm | associated_with | process | 0.82 |
| Premature Infant Health | associated_with | phenotype | 0.75 |
| OBESITY | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 29453413 | may mechanistically explain | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d | validation | inflammatory bowel disease | 0.900 | 0.00 | IL-10 knockout mice | proposed | N/A |
| PGC-1α knockout analysis of PV+ interneuron maturation | validation | neurodevelopmental disorders | 0.850 | 0.00 | knockout mice | proposed | N/A |
| AhR transcriptional regulation of NEP gene | exploratory | Alzheimer's disease | 0.850 | 0.00 | Cell culture system | proposed | N/A |
| PV+ interneuron subtype diversification analysis | exploratory | neurodevelopmental disorders | 0.750 | 0.00 | mouse cortical PV+ interneuron | proposed | N/A |
| Gut-Brain Axis Pathogenesis in Parkinson's Disease — Mechanism and Int | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propagation | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Microbiome-Gut Barrier Signatures in ALS — Experiment Design | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism and inter | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| SCFA-Mediated Neuroinflammation in Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Pseudostellaria heterophylla polysaccharide mitigates Alzheimer's-like pathology [PMID:38750854] | He C, Jiang J, Liu J, Zhou L, Ge Y, Yang | International journal of biolo | 2024 | 1 |
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| Therapeutic strategies for hypertension: exploring the role of microbiota-derive [PMID:40637840] | Tortelote GG | Pediatr Nephrol | 2026 | 0 |
| Exploring the gut-kidney axis: Berberine's role in alleviating chronic kidney di [PMID:41344525] | Lu Z, Li Z, Gu S, Cai Y, Wu Y et al. | J Ethnopharmacol | 2026 | 0 |
| Rebalancing the inflammatory niche in allergic rhinitis ". [PMID:41360358] | Wang N, Tang Y | Clin Chim Acta | 2026 | 0 |
| Differentiating Damp-Heat and Cold-Damp Diarrhea in Rat Models via Gut Microbiot [PMID:41566926] | Zhang H, Song X, Mi W, Ji P, Wei Y et al | Microbiologyopen | 2026 | 0 |
| Cranberry extract-supplemented microbiota effluents enhance intestinal barrier i [PMID:41680408] | Cattero V, Mayer T, Veilleux A, Roussel | Scientific reports | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Iron and the Intestinal Microbiome. [PMID:40603801] | Li H | Adv Exp Med Biol | 2025 | 0 |
| Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP- [PMID:40958035] | Li Z, Sun X, Wang Y | Basic Res Cardiol | 2025 | 0 |
| Exploring the Role of Microglial Cells in the Gut-Brain Axis Communication: A Sy [PMID:40662222] | Ortiz-Samur NS, Vijaya AK, Burokas A, Me | Journal of neurochemistry | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurod [PMID:40640940] | Wang N, Sun C, Yang Y | J Neuroinflammation | 2025 | 0 |
| Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431] | Wang W, Wang Y, Wang F, Xie G, Liu S, Li | Phytomedicine : international | 2024 | 0 |
| Joint-specific memory, resident memory T cells and the rolling window of opportu [PMID:38600215] | Chang MH, Fuhlbrigge RC, Nigrovic PA | Nat Rev Rheumatol | 2024 | 0 |
| Oral Microbiome: A Review of Its Impact on Oral and Systemic Health. [PMID:39338471] | Rajasekaran JJ, Krishnamurthy HK, Bosco | Microorganisms | 2024 | 0 |
| Microglia and gut microbiota: A double-edged sword in Alzheimer's disease. [PMID:39321881] | Bano N, Khan S, Ahamad S, Kanshana JS, D | Ageing research reviews | 2024 | 0 |
| The Gut Microbiota Modulates Neuroinflammation in Alzheimer's Disease: Elucidati [PMID:39460538] | ["Yang Jianshe", "Liang Junyi", "Hu Niyu | CNS neuroscience & therapeutic | 2024 | 0 |
| Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431] | Wang W, Wang Y, Wang F, Xie G, Liu S, Li | Phytomedicine : international | 2024 | 0 |
| Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting n [PMID:36601662] | ["Zhang Di", "Jing Bei", "Chen Zhen-Ni", | CNS neuroscience & therapeutic | 2023 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Microbiome in their description or question text
Score: 0.427 · neurodegeneration · 2026-04-02
Beneficial gut bacteria convert dietary tryptophan into neuroprotective metabolites like indole-3-propionic acid, which
Score: 0.346 · neurodegeneration · 2026-04-26
A longitudinal biomarker panel centered on plasma LPS-binding protein can distinguish harmful mechanisms from protective
Score: 0.343 · neurodegeneration · 2026-04-26
The gap can be tested by treating TLR4 priming as an upstream driver rather than a passive correlate. If true, perturbin
Score: 0.341 · neurodegeneration · 2026-04-26
The same signal may be beneficial early and damaging late. Testing microglial inflammasome tone with dietary fiber chall