gene

CD59

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD59: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

11Outgoing

12Incoming

0Experiments

0Debates

Summary

CD59 is a GPI-anchored complement regulatory protein that inhibits MAC formation. Expressed on neurons and glia, it protects against complement-mediated neurotoxicity in MS, stroke, and AD.

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🧬 Gene Info

Gene Symbol	CD59
Function	encodes a GPI-anchored cell surface glycoprotein that serves as a key complement regulatory protein.
Amino Acids	171 aa
Pathways	Complement, Apoptosis, JAK-STAT signaling, NF-kB signaling
Ensembl ID	ENSG00000085059
GeneCards	CD59
Human Protein Atlas	CD59
All nucleated cells	broad constitutive expression
Neurons	particularly in hippocampus and cortex
Associated Diseases	Alzheimer's disease
Interactions	APOPTOSIS, BCL-2, C3, C4B, CD46, CD55
KG Connections	23 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CD59 Gene

gene · 719 words

→

CD59 Protein

protein · 627 words

→

Pathway Diagram

graph TD
    CD59["CD59"]
    Cancer{"Cancer"}
    CD59 -->|"therapeutic_target"| Cancer
    Tumor{"Tumor"}
    CD59 -->|"activates"| Tumor
    CANCER["CANCER"]
    CD59 -->|"therapeutic_target"| CANCER
    Complement(["Complement"])
    CD59 -->|"activates"| Complement
    Apoptosis(["Apoptosis"])
    CD59 -->|"activates"| Apoptosis
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"activates"| CD59
    FAS["FAS"]
    FAS -->|"activates"| CD59
    AND["AND"]
    AND -->|"expressed_in"| CD59
    BCL_2["BCL-2"]
    BCL_2 -->|"activates"| CD59
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| CD59
    neurodegeneration["neurodegeneration"]
    CD59 -->|"implicated_in"| neurodegeneration

Outgoing (11)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
neurons	expressed_in	cell_type	0.65
CANCER	therapeutic_target	gene	0.60
Complement	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
STAT3	activates	gene	0.55
IDE	activates	gene	0.55
JAK2	activates	gene	0.55
JAK-STAT signaling	participates_in	pathway	0.55
NF-kB signaling	participates_in	pathway	0.55

Incoming (12)

Source	Relation	Type	Str
CD46	regulates	gene	0.65
COMPLEMENT	activates	gene	0.60
BCL-2	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
FAS	activates	gene	0.60
CD55	activates	gene	0.55
CD55	regulates	gene	0.55
C4B	activates	gene	0.55
CD46	activates	gene	0.55
C3	inhibits	gene	0.55
CD46	inhibits	gene	0.55
CD55	inhibits	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD59 in their description or question text

No additional research found