concept

ALZHEIMER'S_DISEASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALZHEIMER'S_DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

30Hypotheses

1Analyses

4Outgoing

15Incoming

15Experiments

1Debates

No summary available yet.

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💡 Concept Info

Name	ALZHEIMER'S_DISEASE
Key Genes/Proteins	AMYLOID_BETA, APP, ASK1, DOR, MICROGLIA, MICRORNAS
Related Diseases	HEARING_LOSS, INSULIN_RESISTANCE, SLEEP_DISTURBANCE

Pathway Diagram

graph TD
    ALZHEIMER_S_DISEASE[ALZHEIMER'S_DISEASE]
    ALZHEIMER_S_DISEASE -->|causes| SLEEP_DISTURBANCE[SLEEP_DISTURBANCE]
    ALZHEIMER_S_DISEASE -->|causes| synaptic_loss[synaptic_loss]
    ALLO[ALLO] -->|treats| ALZHEIMER_S_DISEASE
    GLUCOSE_METABOLISM[GLUCOSE_METABOLISM] -->|implicated in| ALZHEIMER_S_DISEASE
    NNMT[NNMT] -->|implicated in| ALZHEIMER_S_DISEASE
    PARTICULATE_MATTER[PARTICULATE_MATTER] -->|causes| ALZHEIMER_S_DISEASE
    GUT_MICROBIOTA[GUT_MICROBIOTA] -->|implicated in| ALZHEIMER_S_DISEASE
    AMYLOID_BETA[AMYLOID_BETA] -->|causes| ALZHEIMER_S_DISEASE
    INSULIN_RESISTANCE[INSULIN_RESISTANCE] -->|contributes to| ALZHEIMER_S_DISEASE

Outgoing (4)

Target	Relation	Type	Str
PS1	associated_with	gene	0.80
synaptic_loss	causes	process	0.80
SLEEP_DISTURBANCE	causes	phenotype	0.80
APP	associated_with	gene	0.80

Incoming (15)

Source	Relation	Type	Str
BBB_breakdown	precedes	process	0.00
SYNAPSE	disrupts	gene	0.90
SYNAPSE	associated_with	gene	0.90
ASK1	associated_with	protein	0.90
DOR	associated_with	gene	0.80
MICROGLIA	associated_with	gene	0.80
GLUCOSE_METABOLISM	implicated_in	process	0.80
AMYLOID_BETA	causes	protein	0.80
ALLO	treats	compound	0.80
NNMT	implicated_in	gene	0.80
HEARING_LOSS	associated_with	phenotype	0.80
PARTICULATE_MATTER	causes	compound	0.80
GUT_MICROBIOTA	implicated_in	process	0.80
MICRORNAS	associated_with	gene	0.70
INSULIN_RESISTANCE	associated_with	phenotype	0.70

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.958	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.912	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.865	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxic	0.827	neurodegeneration	Legacy Pre-Pipeline Hypothesis Import
Closed-loop transcranial focused ultrasound to restore hippo	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode

ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	Alzheimer's disease	Circuit-level neural dynamics in neurode
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.779	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Closed-loop transcranial focused ultrasound to restore hippo	0.773	Alzheimer's disease	Circuit-level neural dynamics in neurode
Complement C1q-Mediated Synaptic Pruning Drives Early Cognit	0.769	neurodegeneration	Legacy Pre-Pipeline Hypothesis Import
Closed-loop transcranial focused ultrasound to restore hippo	0.767	Alzheimer's disease	Circuit-level neural dynamics in neurode
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.747	neurodegeneration	Are interneuron oscillation deficits com
Excessive C1q/C3/CR3 complement cascade activation initiates	0.720	neurodegeneration	Synaptic pruning by microglia in neurode
Regional TREM2-Dependent Lipid Metabolism Determines Cortica	0.714	neuroinflammation	How do regional, age, and sex-dependent
Closed-loop transcranial focused ultrasound targeting EC-II	0.704	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2-Dependent Microglial State Transition as Therapeutic W	0.690	neurodegeneration	Gap 006 analysis (archived stub)
NMN Adenosine Transport Enhancement for Cortical Neuron Sene	0.680	neurodegeneration	-
Endothelial miR-181c-5p Upregulation Drives Claudin-5 Repres	0.645	-	What blood-brain barrier permeability ch
Microglial TREM2 downregulation impairs damage-associated re	0.626	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma O	0.625	Alzheimer's disease	-
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.622	Alzheimer's disease	Circuit-level neural dynamics in neurode
Epigenetic Memory Reprogramming for Alzheimer's Disease	0.611	neurodegeneration	CRISPR-based therapeutic approaches for
Optogenetic restoration of hippocampal gamma oscillations vi	0.584	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting entorh	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time closed-loop transcranial focused ultrasound target	0.559	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.555	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.551	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.735

Experiments (15)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	0.00	mouse models of Alzheimer's di	proposed	N/A
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A
Closed-loop tFUS Enhances Glymphatic Clearance and Restores CA1 PV Int	in_vivo	Alzheimer's disease	0.765	0.55	APP/PS1 mice 8-11 months (n=10	abandoned	$125,000
Single nuclei transcriptomic and epigenomic profiling of 84 donors acr	gene_expression	Alzheimer's disease	0.500	0.00	human	extracted	N/A
The Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) integrates n	neuropathology	Alzheimer's disease	0.500	0.00	human	extracted	N/A
In late life, NfL demonstrated the strongest association with incident	clinical	Alzheimer's disease	0.500	0.00	human	extracted	N/A
Complex gene expression differences were identified, ranging from glob	gene_expression	Alzheimer's disease	0.500	0.00	post_mortem_brain	extracted	N/A
A subset of donors with particularly severe cellular and molecular phe	clinical	Alzheimer's disease	0.500	0.00	human	extracted	N/A
Midlife hypertension was associated with 0.15-SD faster NfL increase a	clinical	Alzheimer's disease	0.500	0.00	human	extracted	N/A
A subset of donors exhibited particularly severe cellular and molecula	computational	Alzheimer's disease	0.500	0.00	human	extracted	N/A
Cell type-specific analysis identified early-phase loss of somatostati	gene_expression	Alzheimer's disease	0.500	0.00	human	extracted	N/A
Single-cell/multiomics analysis of 84 human post-mortem brains reveale	computational	Alzheimer's disease	0.500	0.00	human	extracted	N/A
Temporal analysis of gene expression differences across disease progre	gene_expression	Alzheimer's disease	0.500	0.00	human	extracted	N/A

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Retinal Müller glia alterations and their impact on ocular glymphatic clearance [PMID:41603340]	Das G, Raghunathan R, Wang L	J Alzheimers Dis	2026
The Glymphatic-Venous Axis in Brain Clearance Failure: Aquaporin-4 Dysfunction, [PMID:41226584]	["Costea D", "Dobrin N", "Tataru C", "To	International journal of molec	2025
Longitudinal changes of blood-brain barrier and transcytolemmal water exchange p [PMID:40089221]	Xiong C, Yu Z, Yin Y	Neuroimage	2025
The future of biomarkers for vascular contributions to cognitive impairment and [PMID:40542975]	Lennon MJ, Karvelas N, Ganesh A	Geroscience	2025
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024
Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Trea [PMID:37047492]	Unknown	Int J Mol Sci	2023
Pathogenesis of Alzheimer's Disease. [PMID:36613544]	Unknown	Int J Mol Sci	2022
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890]	Burillo J, Marqués P, Jiménez B, Gonzále	Cells	2021
Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasou [PMID:32999351]	Lee Y, Choi Y, Park EJ	Sci Rep	2020
Alzheimer's disease. [PMID:31753135]	["Soria Lopez, Jose A", "Gonz\u00e1lez,	Handbook of clinical neurology	2019
Alzheimer's disease. [PMID:28872215]	["Lane, C A", "Hardy, J", "Schott, J M"]	European journal of neurology	2018
Current understanding of Alzheimer's disease diagnosis and treatment. [PMID:30135715]	["Weller, Jason", "Budson, Andrew"]	F1000Research	2018
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169]	["Oakley, Holly", "Cole, Sarah L", "Loga	The Journal of neuroscience :	2006
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773]	["Hardy, John", "Selkoe, Dennis J"]	Science (New York, N.Y.)	2002

Debates (1)

Multi-agent debates referencing this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning ALZHEIMER'S_DISEASE in their description or question text

ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degen

Score: 0.801 · Alzheimer's Disease · 2026-04-05

## Mechanistic Overview ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzhe

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Score: 0.797 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with real-time gamma f

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

Score: 0.784 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activate AMPK-autophag

ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlie

Score: 0.779 · Alzheimer's Disease · 2026-04-05

## Mechanistic Overview ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlies White Matter D

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.773 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct

Complement C1q-Mediated Synaptic Pruning Drives Early Cognitive Decline in Alzhe

Score: 0.769 · neurodegeneration · 2026-04-26

C1q (classical complement cascade initiator) is upregulated in AD brain and tags synapses for microglial phagocytosis vi

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.767 · Alzheimer's disease · 2026-04-12

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via somato

C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV Interneuron Input Eli

Score: 0.747 · neurodegeneration · 2026-04-15

**Molecular Mechanism and Rationale** The complement system's classical pathway, initiated by C1q complex formation, re

Excessive C1q/C3/CR3 complement cascade activation initiates pre-symptomatic syn

Score: 0.720 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The complement cascade represents a critical innate immune system that, when dysr

Regional TREM2-Dependent Lipid Metabolism Determines Cortical Vulnerability in A

Score: 0.714 · neuroinflammation · 2026-04-22

## Mechanistic Overview Regional TREM2-Dependent Lipid Metabolism Determines Cortical Vulnerability in Alzheimer's Disea

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

Score: 0.704 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to prevent tau prop

TREM2-Dependent Microglial State Transition as Therapeutic Window in Alzheimer's

Score: 0.690 · neurodegeneration · 2026-04-22

## Mechanistic Overview TREM2-Dependent Microglial State Transition as Therapeutic Window in Alzheimer's Disease starts

Endothelial miR-181c-5p Upregulation Drives Claudin-5 Repression and Paracellula

Score: 0.645 · unknown disease · 2026-04-26

Circulating miR-181c-5p is upregulated in AD patients and directly targets the CLDN5 3'-UTR, suppressing claudin-5 expre

Microglial TREM2 downregulation impairs damage-associated response in late-stage

Score: 0.626 · Alzheimer's disease · 2026-04-04

## Mechanistic Overview Microglial TREM2 downregulation impairs damage-associated response in late-stage Alzheimer's dis