| Gene Symbol | ADAM8 |
| Full Name | A Disintegrin And Metalloproteinase domain 8 |
| Aliases | ADAM8PROTEIN |
| Chromosome | 10q26.3 |
| Function | is a member of the ADAM (A Disintegrin And Metalloproteinase) family of zinc-dependent metalloproteases. |
| Primary Expression | immune cells and in the brain, particularly in microglia, astrocytes, and neurons |
| Subcellular Localization | </span><span class="infobox-value">Plasma membrane, Cell surface, Leukocyte granules</span></div> |
| Amino Acids | 833 aa |
| UniProt ID | [O43506](https://www.uniprot.org/uniprot/O43506) |
| Ensembl ID | ENSG00000151617 |
| GeneCards | ADAM8 |
| Human Protein Atlas | ADAM8 |
| Prodomain | Maintains enzyme latency until activation |
| Metalloproteinase Domain | Catalytic domain with HEXGHNLG motif |
| Disintegrin Domain | Mediates protein-protein interactions |
| Associated Diseases | Cancer, Leukemia, Lung Cancer |
| Interactions | AND, ANXA2, APOPTOSIS, AUTOPHAGY, BAX, BAX/BCL2 |
| KG Connections | 76 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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