concept

SGMS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SGMS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

109Connections

0Hypotheses

1Analyses

50Outgoing

37Incoming

0Experiments

1Debates

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💡 Concept Info

Name	SGMS2
Key Genes/Proteins	ABCA1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOPTOSIS
Related Diseases	als, Als, ALS, alzheimer, Alzheimer
Related Pathways	Amyloid, apoptosis, Apoptosis

Pathway Diagram

graph TD
    SGMS2["SGMS2"]
    SGMS2 -->|"involved_in"| Sphingomyelin_Biosynthesis["Sphingomyelin Biosynthesis"]
    SGMS2 -->|"activates"| Alzheimer["Alzheimer"]
    SGMS2 -->|"inhibits"| Als["Als"]
    SGMS2 -->|"expressed in"| Ischemia["Ischemia"]
    SGMS2 -->|"expressed in"| Stroke["Stroke"]
    SGMS2 -->|"inhibits"| ALS["ALS"]
    AMYLOID__["AMYLOID Beta"] -->|"downregulates"| SGMS2
    h_fdb07848["h-fdb07848"] -->|"targets"| SGMS2
    FTY720["FTY720"] -->|"upregulates"| SGMS2
    SGMS1["SGMS1"] -->|"interacts"| SGMS2
    GENES["GENES"] -->|"contributes to"| SGMS2
    AND["AND"] -->|"expressed in"| SGMS2
    APOPTOSIS["APOPTOSIS"] -->|"contributes to"| SGMS2

Outgoing (72)

Target	Relation	Type	Str
Als	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Ischemia	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Stroke	expressed_in	disease	0.65
ALS	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
neurodegeneration	associated_with	disease	0.61
SGMS1	interacts_with	gene	0.61
Aβ	activates	protein	0.60
oligodendrocytes	expressed_in	cell_type	0.60
ALZHEIMER	inhibits	disease	0.60
Japanese encephalitis virus infection	involved_in	disease	0.60
Alzheimer's disease	associated_with	disease	0.60
apoptosis	involved_in	pathway	0.60
sphingomyelin	involved_in	pathway	0.60
rat brain	expressed_in	brain_region	0.60
ceramide metabolism	regulates	pathway	0.60
drug transporters	regulates	protein	0.60
cognitive impairment	protects_against	disease	0.60
membrane raft	involved_in	pathway	0.60
ceramide phosphoethanolamine	involved_in	pathway	0.60
Sphingolipid	activates	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
Amyloid	activates	pathway	0.60
hippocampus	expressed_in	brain_region	0.60
oligodendrocytes	regulates	cell_type	0.60
Sphingolipid	contributes_to	pathway	0.60
Ras	expressed_in	protein	0.60
Fus	expressed_in	protein	0.60
oligodendrocytes	associated_with	cell_type	0.60
oligodendrocytes	inhibits	cell_type	0.60
CERS6	activates	gene	0.60
CERS2	activates	gene	0.60
SGMS1	inhibits	gene	0.60
SGMS1	expressed_in	gene	0.60
ASAH1	activates	gene	0.60
STROKE	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
Lipid Metabolism	contributes_to	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
Neuron	expressed_in	cell_type	0.60
ASAH1	associated_with	gene	0.60
SGMS1	associated_with	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
Apoptosis	contributes_to	pathway	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
Lipid Metabolism	activates	pathway	0.60
sphingolipid metabolism	participates_in	pathway	0.55

Incoming (37)

Source	Relation	Type	Str
h-fdb07848	targets	hypothesis	0.90
SGMS1	regulates	gene	0.70
SGMS1	interacts_with	gene	0.61
SGMS1	associated_with	gene	0.60
GENES	contributes_to	gene	0.60
AND	expressed_in	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
GENES	expressed_in	gene	0.60
AND	contributes_to	gene	0.60
STROKE	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
ASAH1	regulates	gene	0.60
SGMS1	expressed_in	gene	0.60
ASAH1	activates	gene	0.60
CERS6	activates	gene	0.60
SGMS1	inhibits	gene	0.60
CERS2	activates	gene	0.60
ASAH1	contributes_to	gene	0.60
ABCA1	debate_co_mention	gene	0.45
BACE1	debate_co_mention	gene	0.45
CYP46A1	debate_co_mention	gene	0.45
SGMS1	co_discussed	gene	0.40
SMPD1	co_discussed	gene	0.40
apoptosis	co_mentioned	pathway	0.40
ABCA1	co_discussed	gene	0.40
FLOT1	co_discussed	gene	0.40
SREBF2	co_discussed	gene	0.40
CYP46A1	co_discussed	gene	0.40
ST8SIA1	co_discussed	gene	0.40
LDLR	co_discussed	gene	0.40
BACE1	co_discussed	gene	0.40
ST3GAL2	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.921

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c

closed · Rounds: 5 · Score: 0.93 · 2026-04-11

Related Research

Hypotheses and analyses mentioning SGMS2 in their description or question text

No additional research found