protein 660 words KG: TUBULIN
Contents

Tubulin Protein

🔬 Protein Info
Gene SymbolTUBULIN
Protein FamilyTubulin family
Functionis a protein encoded by the TUBB gene.
Subcellular LocalizationMicrotubules, cytoplasm
Molecular Weight55 kDa
Amino Acids4477 aa
PathwaysAutophagy, Phagocytosis, Proteasome, Ubiquitin-Proteasome
UniProt IDP07437
GeneCardsTUBULIN
Human Protein AtlasTUBULIN
Axonal transportProvide tracks for kinesin and dynein motor proteins[@vallee2005]
Neuronal polarityEstablish axon-dendrite polarity during development[@baas1999]
Synaptic functionRegulate synaptic vesicle trafficking and presynaptic release[@lee2000]
Intracellular traffickingTransport organelles, proteins, and RNA within neurons[@hirokawa1989]
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ms, Pyroptosis
InteractionsACHE, ACTB, Actin, AGING, ALZHEIMER, ALZHEIMER DISEASE
KG Connections422 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (14)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Lysosomal Positioning Dynamics Modulation
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.56

Related Analyses (13)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (4)

Validation: Membrane-Nucleation in iPSC Neurons
validation · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40
s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · completed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: causes
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
ACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TAU interacts_with TUBULIN
TUBULIN associated_with P62
TUBULIN associated_with MAP3K5
TUBULIN associated_with UBIQUITIN
TUBULIN associated_with OCLN
TUBULIN regulates GJA1
TUBULIN associated_with SQSTM1
TUBULIN regulates CASP3
TUBULIN regulates GAPDH
TUBULIN regulates ACTB

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