protein 2,434 words KG: TRKB
Contents

TrkB Protein

🔬 Protein Info
Gene SymbolTRKB
Chromosome9q21.33
Protein TypeReceptor
Functionis a high-affinity receptor tyrosine kinase that serves as the primary signaling receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4).
Subcellular Localization</th><td>Cell membrane, endosomes, nucleus, mitochondria</td></tr>
Molecular Weight140 kDa
Amino Acids796 aa
Exons24
PathwaysAkt, Apoptosis, Cell Cycle, Long-Term Potentiation, Mapk
UniProt IDQ16620
NCBI Gene ID4915
Ensembl IDENSG00000148053
GeneCardsTRKB
Human Protein AtlasTRKB
Associated DiseasesAging, Als, Alzheimer, Alzheimer'S Disease, Cancer
InteractionsACHE, Actin, ADAM10, AEP, AGING, AKT
KG Connections917 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (23)

Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
Vocal Cord Neuroplasticity Stimulation
Score: 0.52
Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48
← Prevpg 2/2

Related Analyses (15)

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Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (1)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (2)

Alzheimer Indonesia
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates

Knowledge Graph (12 edges)

BDNF activates TRKB
BDNF interacts_with TRKB
MMP9 activates TRKB
TRKB activates MMP2
TRKB activates SYN3
TRKB activates MMP9
TRKB activates BDNF
BAX therapeutic_target TRKB
TRKB therapeutic_target RB1
TRKB regulates PI3K

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