protein 2,968 words KG: TMEM175
Contents

TMEM175 Protein

🔬 Protein Info
Gene SymbolTMEM175
Protein TypeProtein
Functionis a lysosomal potassium channel that plays critical roles in neuronal function and survival.
Amino Acids522 aa
PathwaysLysosomal pH Homeostasis
UniProt IDSearch UniProt
GeneCardsTMEM175
Human Protein AtlasTMEM175
Associated DiseasesAls, Ms, Neurodegeneration, Parkinson, Parkinson's Disease
InteractionsAKT, ALS, AUTOPHAGY, CHCHD10, FUS, GBA
KG Connections120 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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Related Hypotheses (6)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.98
APOE-Dependent Autophagy Restoration
Score: 0.88
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (8)

GBA (Redirect)
redirect · KG edge: associated_with
GBA1 (Redirect)
redirect · KG edge: implicated_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: contributes_to
CTSB Gene
gene · KG edge: associated_with
JUN Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

JUN inhibits TMEM175
TMEM175 associated_with REM sleep behavior disorder
SCARB2 associated_with TMEM175
SNCA-AS1 associated_with TMEM175
TMEM175 contributes_to TFEB
TMEM175 contributes_to GBA
TMEM175 inhibits JUN
TMEM175 regulates Lysosomal Function
LAMP1 interacts_with TMEM175
LAMP2 interacts_with TMEM175

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