protein 643 words KG: GSTP1
Contents

GSTP1 Protein (Glutathione S-Transferase Pi 1)

🔬 Protein Info
Gene SymbolGSTP1
AliasesGlutathione S-Transferase Pi 1
Chromosome11q13.2
Protein FamilyPi class glutathione S-transferase family
Protein TypeEnzyme
Subcellular LocalizationCytoplasm, nucleus
Molecular Weight23 kDa
Amino Acids198 aa
PathwaysSignaling:** Interacts with TNF receptor, MAPK, NF-κB
UniProt IDGSTP1
Ensembl IDENSG00000042832
GeneCardsGSTP1
Human Protein AtlasGSTP1
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Anxiety, Dementia
Known Drugs/CompoundsGalangin
InteractionsAND, C-JUN, CYTOKINES, DNA, FERROPTOSIS, GAL
KG Connections144 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (12)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (8)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: associated_with
ADRA2A Gene
gene · KG edge: associated_with
ADRB2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MAOB associated_with GSTP1
GABRA1 associated_with GSTP1
CHAT associated_with GSTP1
CYP2D6 associated_with GSTP1
APOE associated_with GSTP1
HMGCR associated_with GSTP1
OPRM1 associated_with GSTP1
SLC30A8 associated_with GSTP1
COMT associated_with GSTP1
NBEA associated_with GSTP1

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