| Gene Symbol | FUS |
| Full Name | FUS (Fused in Sarcoma) |
| Chromosome | 16p11.2. |
| Protein Type | Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Pathways | Blood-Brain Barrier, Hippo Pathway, Oxidative Stress, Sod1, Tdp-43 |
| UniProt ID | Search UniProt |
| GeneCards | FUS |
| Human Protein Atlas | FUS |
| RGG1 domain (residues 165–267) | The first arginine-glycine-glycine repeat region, which contributes to RNA binding and phase separation through electrostatic interactions. |
| RGG2 domain (residues 370–422) | The second RGG repeat region. |
| RGG3 domain (residues 453–501) | The third RGG repeat region. |
| mRNA Transport | FUS is a component of neuronal RNA granules and facilitates mRNA transport along axons and dendrites, delivering transcripts to sites of local translation at synapses and growth cones. |
| microRNA Processing | FUS promotes Drosha-mediated processing of specific microRNA precursors, linking it to post-transcriptional gene regulation.[@fusco2012] |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | ADUCANUMAB, Antisense Oligonucleotide, Rna Oligonucleotides, RNA oligonucleotides |
| Interactions | ACTB, Actin, AD, AGING, ALPHA-SYNUCLEIN, ALS |
| SciDEX Hypotheses | ASO-Mediated Exon Skipping to Restore FUS-TAZ Chap FUS Mutations Alter Stress Granule Material Proper FUS Mutations Impede G3BP1's Chaperone Function, E |
| KG Connections | 1547 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!