gene 699 words KG: TRPC1
Contents

TRPC1 Gene

🧬 Gene Info
Gene SymbolTRPC1
Full NameTransient Receptor Potential Cation Channel Subfamily C Member 1
Chromosome3q23
Protein TypeChannel
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionUbiquitous - Brain, Heart, Skeletal muscle, Endothelium
Molecular Weight90 kDa
Amino Acids793 aa
Exons13
UniProt IDP48995
NCBI Gene ID7220
Ensembl IDENSG00000113615
OMIM602409
GeneCardsTRPC1
Human Protein AtlasTRPC1
Associated DiseasesAlzheimer's Disease, Parkinson's Disease, Stroke
InteractionsAND, APOE4, FOXO, FSP1, Fus, GENES
KG Connections33 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

DEX effects on K2P channel transcriptome in mouse TM cells
exploratory · proposed · Score: 0.90

See Also (7)

Neurodegeneration
disease · KG edge: implicated_in
FUS (Redirect)
redirect · KG edge: activates
Genes
index · KG edge: activates
FSP1 Gene - Ferroptosis Suppressor Protein 1
gene · KG edge: activates
KCNK2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PIEZO1 activates TRPC1
KCNK2 activates TRPC1
TRPC1 activates TRPV4
TRPC1 activates FSP1
TRPC1 activates PIEZO1
TRPC1 activates KCNK2
FSP1 activates TRPC1
FSP1 inhibits TRPC1
KCNK2 inhibits TRPC1
PIEZO1 inhibits TRPC1

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.