protein 509 words KG: FAS
Contents

FAS Protein

🔬 Protein Info
Gene SymbolFAS
Protein FamilyTNF receptor superfamily
Protein TypeReceptor
FunctionFAS (also known as CD95 or APO-1) is a cell surface receptor that triggers apoptosis upon binding with its ligand FASLG
Primary Expressionneurons and glial cells throughout the brain and plays roles in developmental apoptosis, immune surveillance, synaptic pruning, a
Subcellular LocalizationPlasma membrane
Molecular Weight43 kDa
Pathwayspathway: ### Activation Cascade
UniProt IDP01375
GeneCardsFAS
Human Protein AtlasFAS
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, AMI
InteractionsA2M, ACETYL-COA, AGING, AKT, ALS, ALZHEIMER
KG Connections595 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

UniProtWikipedia

Related Hypotheses (24)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
← Prevpg 2/2

Related Analyses (13)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

See Also (8)

acc-chronic-pain
cell_type · KG edge: expressed_in
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with
A2M Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

NCSTN interacts_with FAS
FAS activates TNF
FAS interacts_with LMNA
FAS interacts_with APH1B
FAS interacts_with APOE
FAS activates IL6
FAS interacts_with SREBF1
FAS interacts_with PSEN2
FAS interacts_with A2M
FAS interacts_with DHCR24

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.