protein 509 words KG: FAS
Contents

FAS Protein

🔬 Protein Info
Gene SymbolFAS
Protein FamilyTNF receptor superfamily
Protein TypeReceptor
FunctionFAS (also known as CD95 or APO-1) is a cell surface receptor that triggers apoptosis upon binding with its ligand FASLG
Primary Expressionneurons and glial cells throughout the brain and plays roles in developmental apoptosis, immune surveillance, synaptic pruning, a
Subcellular LocalizationPlasma membrane
Molecular Weight43 kDa
Pathwayspathway: ### Activation Cascade
UniProt IDP01375
GeneCardsFAS
Human Protein AtlasFAS
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, AMI
InteractionsA2M, ACETYL-COA, AGING, AKT, ALS, ALZHEIMER
KG Connections595 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (24)

APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Glial Glycocalyx Remodeling Therapy
Score: 0.65
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Related Analyses (13)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

See Also (8)

acc-chronic-pain
cell_type · KG edge: expressed_in
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with
A2M Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

NCSTN interacts_with FAS
FAS activates TNF
FAS interacts_with LMNA
FAS interacts_with APH1B
FAS interacts_with APOE
FAS activates IL6
FAS interacts_with SREBF1
FAS interacts_with PSEN2
FAS interacts_with A2M
FAS interacts_with DHCR24

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