protein 1,550 words KG: ERK2
Contents

ERK2 Protein

🔬 Protein Info
Gene SymbolMAPK1
Full NameMitogen-Activated Protein Kinase 1
AliasesERK2
Chromosome22q11.22
Protein TypeKinase
Functionis a serine/threonine protein kinase that serves as a central mediator of intracellular signal transduction.
Subcellular Localization</th><td>Cytoplasm, nucleus</td></tr> [@roskoski2012]
Molecular Weight42 kDa
Amino Acids360 aa
PathwaysMAPK, Mapk, MAPK signaling
UniProt IDP28482
NCBI Gene ID5594
Ensembl IDENSG00000100030
GeneCardsMAPK1
Human Protein AtlasMAPK1
Associated DiseasesAging, Als, Cancer, Carcinoma, Heart Failure, Melanoma
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, ATF4
KG Connections170 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (8)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67

Related Analyses (9)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
BAX Gene
gene · KG edge: activates
BCL2 Gene
gene · KG edge: activates
BTRC Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PRDX1 regulates ERK2
ERK2 activates DRP1
DRP1 activates ERK2
ERK2 activates ATF4
ERK2 activates TFAM
ERK2 activates BCL2
ERK2 activates BAX
ERK2 activates ERK1
TNF associated_with ERK2
ERK1 associated_with ERK2

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