| Gene Symbol | BTRC |
| Full Name | Beta-Transducin Repeat Containing Protein |
| Chromosome | 10q24.32 |
| Protein Type | Ligase |
| Function | is a critical regulator of numerous cellular processes, including cell cycle progression, DNA damage responses, circadian rhythm, inflammatory signaling, and protein quality control. |
| Amino Acids | 542 aa |
| Pathways | Autophagy, Inflammasome, Mitophagy, Nlrp3 Inflammasome |
| UniProt ID | [Q9Y297](https://www.uniprot.org/uniprot/Q9Y297) |
| Ensembl ID | ENSG00000166167 |
| GeneCards | BTRC |
| Human Protein Atlas | BTRC |
| Recognition motif | DSGxxS or DSxGxxS (where x is any amino acid) |
| Phosphorylation requirement | Both serine residues must be phosphorylated |
| Dimerization requirement | β-TrCP functions as a dimer |
| NF-κB pathway | IκBα, IκBβ, NF-κB2/p100, HBV X protein |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | AUTOPHAGY, CANCER, CYTOKINES, MITOCHONDRIA, MITOPHAGY, NLRP3 |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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