protein 653 words KG: BRAF
Contents

B-Raf Protein

🔬 Protein Info
Gene SymbolBRAF
AliasesRAF kinase in MAPK signaling
Chromosome7q34
Protein FamilyRAF serine/threonine kinases
Protein TypeSerine/Threonine Kinase
FunctionBRAF is a serine/threonine-protein kinase that serves as a key intermediate in the RAS-RAF-MEK-ERK signaling cascade.
Subcellular Localizationand substrate accessibility
Molecular Weight84.5 kDa
Amino Acids766 aa
PathwaysMAPK, mapk
UniProt ID[P15056](https://www.uniprot.org/uniprot/P15056)
GeneCardsBRAF
Human Protein AtlasBRAF
Associated DiseasesAD, Als, Ameloblastoma, cancer
Known Drugs/Compoundsdabrafenib, encorafenib + cetuximab, SORAFENIB, TRAMETINIB
InteractionsABCB1, AGING, AKT, AKT3, ALZHEIMER, AMYLOID
KG Connections589 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (29)

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← Prevpg 2/2

Related Analyses (22)

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See Also (10)

Apoptosis in Neurodegeneration
entity · KG edge: contributes_to
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
Astrocytes
entity · KG edge: co_discussed
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: co_discussed
AKT3 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

BRAF associated_with PILOCYTIC_ASTROCYTOMA
BRAF associated_with AMELOBLASTOMA
IDH1 associated_with BRAF
TERT associated_with BRAF
JUN biomarker_for BRAF
CIC associated_with BRAF
FUBP1 associated_with BRAF
H3F3A associated_with BRAF
OVERVIEW biomarker_for BRAF
BRAF associated_with ATRX

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