| Gene Symbol | BIP |
| Full Name | BiP - Binding Immunoglobulin (GRP78) |
| Aliases | HSPA5/GRP78 |
| Protein Type | Protein |
| Function | De Novo Folding: Binds nascent polypeptide chains as they enter the ER via the Sec61 translocon |
| Molecular Weight | 78 kDa |
| Amino Acids | 654 aa |
| Pathways | Autophagy, Mapk, Mtor, Pi3K/Akt, Unfolded Protein Response |
| UniProt ID | P11021 |
| GeneCards | BIP |
| Human Protein Atlas | BIP |
| Substrate-Binding Domain (SBD) | The C-terminal 25 kDa domain binds to hydrophobic stretches on unfolded proteins. Comprises: |
| Associated Diseases | Tumor |
| Interactions | ACETYL-COA, AKT, AND, ANXIETY, APOPTOSIS, ARC |
| KG Connections | 177 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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