gene 636 words KG: NCOA4
Contents

NCOA4 Gene

🧬 Gene Info
Gene SymbolNCOA4
Full NameNuclear Receptor Coactivator 4
Chromosome10q11.23
Protein TypeReceptor
FunctionNCOA4 performs two major functions in the cell:
Primary Expressionhuman tissues: - Brain: Moderate expression in cortex, hippocampus, basal ganglia - Highe
Molecular Weight70 kDa
PathwaysAkt, Autophagy, FERRITINOPHAGY, Ferroptosis, Iron Metabolism
UniProt IDQ9UBR1
NCBI Gene ID8031
Ensembl IDENSG00000135333
OMIM605161
GeneCardsNCOA4
Human Protein AtlasNCOA4
Associated DiseasesCarcinoma, Cardiovascular, Hepatocellular Carcinoma, Lactation Dysfunction, Parkinson, Tumor
Known Drugs/Compoundsrapamycin, Salidroside
InteractionsACETYL-COA, ACSL4, ACTB, AGER, ALOX, ALZHEIMER
SciDEX HypothesesFUS-ALS-Specific Ferroptosis Vulnerability Through
KG Connections455 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

Lamin B1 Degradation as Irreversibility Gate
Score: 0.49
FUS-ALS-Specific Ferroptosis Vulnerability Through NCOA4-Med
Score: 0.48

Knowledge Graph (12 edges)

SLC7A11 inhibits NCOA4
NCOA4 inhibits GPX4
MAP1LC3B associated_with NCOA4
GPX4 associated_with NCOA4
BMAL1 associated_with NCOA4
LC3 associated_with NCOA4
NCOA4 associated_with ARNTL
NCOA4 associated_with CGAS
NCOA4 associated_with SLC7A11
NCOA4 associated_with TMEM173

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