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TBK1-Mediated Neuroinflammation Hypothesis — Impaired Autophagy and Innate Immune Dysregulation in FTD/ALS

🔬 Protein Info

Gene Symbol	TBK1
Full Name	Mediated Neuroinflammation Hypothesis: Autophagy Failure Drives FTD/ALS
Chromosome	12q14.2
Protein Type	Serine/Threonine Kinase
Function	TBK1 belongs to the IκB kinase (IKK) subfamily of kinases, originally characterized for its role in activating innate immune signaling through the induction of type I interferons in response to viral
Primary Expression	Motor cortex, Spinal cord, Immune cells
Molecular Weight	84 kDa
Pathways	Apoptosis, Autophagy, Epigenetic, Er Stress, Immune Response
UniProt ID	Q9UHD2
NCBI Gene ID	29110
Ensembl ID	ENSG00000183735
OMIM	604834
GeneCards	TBK1
Human Protein Atlas	TBK1
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis
Known Drugs/Compounds	amlexanox, rapamycin
Interactions	Actin, AGING, AIM2, AKT, AKT1, ALS
SciDEX Hypotheses	TBK1 Loss-of-Function Amplifies C1q-Mediated Synap TBK1 Phosphorylation State Creates Phospho-Regulat
KG Connections	1279 knowledge graph edges
Databases	GeneCards HPA STRING

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