| Gene Symbol | ent-prot-c9ad802a |
| Small target size | Alpha-synuclein aggregates (10-50 nm) are approximately 100-fold smaller than amyloid plaques, providing fewer binding sites for radioligands |
| Diffuse pathology | Lewy bodies and Lewy neurites are distributed throughout multiple brain regions rather than concentrated in specific areas |
| Intracellular location | Pathological alpha-synuclein is primarily intracellular, requiring tracers to cross the cell membrane |
| Low density | The concentration of aggregated alpha-synuclein in the brain is orders of magnitude lower than amyloid plaques |
| Fibril-selective tracers | Target the beta-sheet structure of aggregated fibrils |
| Oligomer-selective tracers | Preferentially bind to soluble oligomeric species |
| Pan-aggregate tracers | Detect all forms of pathological alpha-synuclein |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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