| Gene Symbol | BIOMARKERS |
| Brain volume differences | Asian populations show smaller average brain volumes, affecting volumetric cutoffs |
| Atrophy patterns | Consistent with Western populations but with adjusted regional thresholds |
| FDG-PET hypometabolism | Similar patterns observed across Asian cohorts |
| Midbrain to pons ratio | May differ due to population-specific brain size variations |
| DTI metrics | Comparable sensitivity and specificity in Asian populations |
| Diagnostic cutoffs | Studies from J-ADNI, Korean, and Chinese cohorts provide validated cutoffs |
| Asymmetric cortical atrophy | Contralateral to more affected side |
| Precentral gyrus involvement | Characteristic "knife-edge" atrophy |
| Parietal lobe atrophy | Especially superior parietal lobule |
| Frontal atrophy | Including orbitofrontal regions |
| Temporal involvement | Often less prominent than frontal/parietal |
| Midbrain atrophy | "Hummingbird sign" on sagittal images |
| Superior cerebellar peduncle atrophy | Characteristic finding |
| Globus pallidus atrophy | T2 hypointensity |
| Thalamic atrophy | Dorsomedial nucleus involvement |
| Associated Diseases | Neurocognitive Disorders, Prostate Cancer, ALS, Frailty, Hepatocellular Carcinoma, Inclusion Body Myositis |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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