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mechanism 1,055 words KG: GABA
Contents

GABA Signaling Pathway

⚙ Mechanism Info
NameGABA
Key Genes/ProteinsABCA7, ACTB, Actin, ADRA2B, Akt, AKT
Related Diseasesacetylcholine, Aging, AGING, Als, ALS
Linked Hypotheses11 hypotheses

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Knowledge Graph

Agent Input

Related Hypotheses (84)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.98Transcriptional Autophagy-Lysosome Coupling
Score: 0.92Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79Senescence-Activated NAD+ Depletion Rescue
Score: 0.76Smartphone-Detected Motor Variability Correction
Score: 0.74Senescence-Associated Myelin Lipid Remodeling
Score: 0.73Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73Adenosine-Astrocyte Metabolic Reset
Score: 0.73Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72Retinal Vascular Microcirculation Rescue
Score: 0.72Purinergic Signaling Polarization Control
Score: 0.71Noradrenergic-Tau Propagation Blockade
Score: 0.71Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71Autophagosome Maturation Checkpoint Control
Score: 0.71Orexin-Microglia Modulation Therapy
Score: 0.71
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Related Analyses (30)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedSleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (3)

Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40Non-Dopaminergic Neurotransmitter Degeneration in PD - Exper
clinical · proposed · Score: 0.40

See Also (7)

acetylcholine
general · KG edge: co_discussedACTB Gene
gene · KG edge: activatesadra2b Gene
gene · KG edge: expressed_inAKT1 Gene
gene · KG edge: interacts_withGene Page: ALS4 (SENATAXIN)
gene · KG edge: activates

Knowledge Graph (12 edges)

GABA associated_with MTOR
GABA associated_with TFEB
AKT associated_with GABA
BACE1 associated_with GABA
TAU associated_with GABA
GABA associated_with neuroinflammation
GABA associated_with serotonin
GABA associated_with GABAergic neurons
GABA interacts_with GABARAP
FLCN interacts_with GABA

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