concept

LPS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LPS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

5Hypotheses

3Analyses

36Outgoing

1Incoming

1Experiments

3Debates

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💡 Concept Info

Name	LPS
Key Genes/Proteins	ACSL4, BAX, BCL2, BDNF, C1Q, GFAP
Related Diseases	Alzheimer's disease, depression, major depressive disorder
Related Pathways	autophagy, MAPK
Linked Hypotheses	5 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

LLPS Modulator Therapy

therapeutic · 1296 words

→

Pathway Diagram

graph TD
    LPS["LPS"]
    LPS -->|"activates"| NF_kappaB["NF-kappaB"]
    LPS -->|"activates"| MAPK["MAPK"]
    LPS -->|"causes"| pulmonary_inflammation["pulmonary inflammation"]
    LPS -->|"causes"| neuroinflammation["neuroinflammation"]
    LPS -->|"causes"| Acute_Lung_Injury["Acute Lung Injury"]
    LPS -->|"activates"| NLRP3_Inflammasome_Activation["NLRP3 Inflammasome Activation"]
    LPS -->|"causes"| Septic_Cardiomyopathy["Septic Cardiomyopathy"]
    LPS -->|"upregulates"| C3["C3"]
    LOXL3["LOXL3"] -->|"modulates"| LPS

Outgoing (36)

Target	Relation	Type	Str
pulmonary inflammation	causes	phenotype	0.90
GFAP	activates	protein	0.90
NF-kappaB	activates	protein	0.90
MAPK	activates	pathway	0.90
C3	upregulates	protein	0.90
Septic Cardiomyopathy	causes	disease	0.90
neuroinflammation	causes	phenotype	0.90
NLRP3 Inflammasome Activation	activates	process	0.90
Ferroptosis	associated_with	process	0.85
NLRP3 Inflammasome Activation	associated_with	process	0.85
GFAP	contributes_to	protein	0.80
autophagy	activates	pathway	0.80
MTOR	activates	gene	0.80
BAX	activates	gene	0.75
Alzheimer's disease	associated_with	disease	0.70
TNF	activates	protein	0.70
TLR4	activates	protein	0.70
NLRP3	activates	protein	0.70
PI3K	activates	protein	0.70
BDNF	regulates	protein	0.70
PINK1	inhibits	protein	0.70
PINK1/Parkin	inhibits	protein	0.70
microglia	activates	cell_type	0.70
ACSL4	induces	protein	0.70
BCL2	inhibits	protein	0.70
mitophagy	inhibits	process	0.70
NLRP3 inflammasome	activates	protein	0.70
MAP1LC3B	inhibits	protein	0.70
major depressive disorder	causes	disease	0.70
NEUROINFLAMMATION	activates	pathway	0.64
PRDX1	inhibits	protein	0.64
MACROPHAGES	activates	cell_type	0.64
MMP9	activates	protein	0.64
depression	causes	disease	0.56
PYROPTOSIS	activates	phenotype	0.56
C1Q	activates	protein	0.56

Incoming (1)

Source	Relation	Type	Str
LRRK2	interacts_with	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target	7.200	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M
TLR4/MyD88/NF-κB Axis Blockade to Interrupt LPS-Mediated Gut	0.703	neurodegeneration	How do gut microbiome-derived metabolite
LPS-primed microglial trained immunity establishes persisten	0.670	neurodegeneration	Synaptic pruning by microglia in neurode
Intestinal Permeability Defects → Systemic LPS Translocation	0.630	neurodegeneration	What are the mechanisms by which gut mic
Liquid-Liquid Phase Separation (LLPS) Saturation Partitionin	0.461	neurodegeneration	What determines the spatial organization