Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about INPP5F: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | INPP5F |
| Key Genes/Proteins | ALPHA-SYNUCLEIN, AUTOPHAGY, DNAJC6, GAK, GBA, GENE MUTATIONS |
| Related Diseases | Als, Ms |
| Related Pathways | Autophagy, autophagy pathway, Endocytosis |
graph TD
INPP5F["INPP5F"]
INPP5F ---|"associated"| REM_sleep_behavior_disorder["REM sleep behavior disorder"]
INPP5F ---|"associated"| Ms["Ms"]
INPP5F ---|"associated"| Synucleinopathy["Synucleinopathy"]
INPP5F ---|"associated"| Parkinson["Parkinson"]
INPP5F ---|"associated"| Als["Als"]
SNCA["SNCA"] ---|"associated"| INPP5F
GBA["GBA"] ---|"associated"| INPP5F
SCARB2["SCARB2"] ---|"associated"| INPP5F
SNCA_AS1["SNCA-AS1"] ---|"associated"| INPP5F
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] ---|"associated"| INPP5F| Target | Relation | Type | Str |
|---|---|---|---|
| REM sleep behavior disorder | associated_with | disease | 0.70 |
| Synucleinopathy | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| DNAJC6 | associated_with | gene | 0.60 |
| GENE MUTATIONS | associated_with | gene | 0.60 |
| PARK2 | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Endocytosis | associated_with | pathway | 0.60 |
| TMEM175 | associated_with | gene | 0.60 |
| GAK | associated_with | gene | 0.60 |
| SYNJ1 | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| NUP153 | regulates | gene | 0.60 |
| STAU2 | regulates | gene | 0.60 |
| Wnt signaling | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| RNA | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SNCA | associated_with | gene | 0.60 |
| GBA | associated_with | gene | 0.60 |
| SCARB2 | associated_with | gene | 0.60 |
| SNCA-AS1 | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| ALPHA-SYNUCLEIN | associated_with | gene | 0.60 |
| PARKIN | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning INPP5F in their description or question text
No additional research found