Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NUP153: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NUP153 |
| Full Name | Nucleoporin 153 |
| Chromosome | 6p22.3 |
| Function | encodes a 1,475-amino acid protein with a molecular weight of approximately 153 kDa. |
| Primary Expression | post-mitotic neurons, where NPCs are extraordinarily long-lived |
| Molecular Weight | 153 kDa |
| Amino Acids | 475 aa |
| UniProt ID | P49790 |
| NCBI Gene ID | 9972 |
| Ensembl ID | ENSG00000124789 |
| OMIM | 603948 |
| GeneCards | NUP153 |
| Human Protein Atlas | NUP153 |
| mRNA export | NUP153 interacts with the TREX-2/GANP mRNA export complex and is required for efficient export of poly(A)+ RNA, including transcripts encoding synaptic proteins |
| RNA foci sequestration | Sense and antisense repeat RNA foci sequester RNA-binding proteins including RANGAP1 and NUP153-interacting transport factors, disrupting the Ran-GTP gradient essential for directional transport |
| Associated Diseases | Alzheimer's Disease, Huntington's Disease |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["NUP153"]
N1["INPP5F"]
N1 -->|"regulates"| N0
N2["STAU2"]
N0 -->|"regulates"| N2
N3["Wnt signaling"]
N0 -->|"participates in"| N3
N4["autophagy pathway"]
N0 -->|"participates in"| N4
N5["RNA"]
N0 -->|"regulates"| N5
N6["neurodegeneration"]
N0 -->|"implicated in"| N6
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class N0 gene
class N1 gene
class N2 gene
class N3 pathway
class N4 pathway
class N5 gene| Target | Relation | Type | Str |
|---|---|---|---|
| STAU2 | regulates | gene | 0.60 |
| Wnt signaling | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| RNA | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INPP5F | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NUP153 in their description or question text
No additional research found