concept

HER3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HER3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

28Outgoing

8Incoming

0Experiments

0Debates

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💡 Concept Info

Name	HER3
Key Genes/Proteins	AND, App, CANCER, ERBB3, Fgf, HER2
Related Diseases	Als, ALS, Cancer, Non-Small Cell Lung Cancer

Wiki Pages (1)

Knowledge base pages for this entity

ERBB3 (HER3) Protein

protein · 581 words

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Pathway Diagram

graph TD
    HER3["HER3"]
    HER3 -.biomarker for.-> Non_Small_Cell_Lung_Cancer["Non-Small Cell Lung Cancer"]
    HER3 -->|"target for"| Als["Als"]
    HER3 -->|"target for"| Cancer["Cancer"]
    HER3 -->|"interacts"| ALS["ALS"]
    HER3 -->|"target for"| PRMT5["PRMT5"]
    ITGB6["ITGB6"] -->|"causes"| HER3
    MEK["MEK"] -->|"causes"| HER3
    KRAS["KRAS"] -->|"target for"| HER3
    PDGFRA["PDGFRA"] -->|"inhibits"| HER3
    RNA["RNA"] -->|"inhibits"| HER3
    ERBB3["ERBB3"] -->|"activates"| HER3

Outgoing (28)

Target	Relation	Type	Str
Non-Small Cell Lung Cancer	associated_with	disease	0.90
Non-Small Cell Lung Cancer	biomarker_for	disease	0.80
Cancer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Cancer	inhibits	disease	0.65
ITGB6	causes	gene	0.60
Rb	activates	protein	0.60
Pdgf	inhibits	protein	0.60
Fgf	activates	protein	0.60
App	inhibits	protein	0.60
Raf	inhibits	protein	0.60
NRG1	activates	gene	0.60
Fibroblast	inhibits	cell_type	0.60
MEK	causes	gene	0.60
PRMT5	causes	gene	0.60
RAF	causes	gene	0.60
CANCER	interacts_with	gene	0.60
KRAS	causes	gene	0.60
Raf	therapeutic_target	protein	0.60
Mek	therapeutic_target	protein	0.60
Ras	therapeutic_target	protein	0.60
PRMT5	therapeutic_target	gene	0.60
ITGB6	therapeutic_target	gene	0.60
KRAS	therapeutic_target	gene	0.60
AND	causes	gene	0.60

Incoming (8)

Source	Relation	Type	Str
ITGB6	causes	gene	0.60
MEK	causes	gene	0.60
ITGB6	therapeutic_target	gene	0.60
KRAS	therapeutic_target	gene	0.60
PDGFRA	inhibits	gene	0.60
RNA	inhibits	gene	0.60
ERBB3	activates	gene	0.60
HER2	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HER3 in their description or question text

No additional research found