| Gene Symbol | NSUN2 |
| Full Name | NOP2/Sun RNA Methyltransferase 2 |
| Chromosome | 5p15.31 |
| Protein Type | Transferase |
| Function | This modification occurs at specific positions within tRNA molecules, particularly at positions 34 (the wobble position) and 48 in the anticodon loop[@bhatt2019]. |
| Primary Expression | Ubiquitous; highest in brain, testis, and gastrointestinal tract |
| Amino Acids | 697 aa |
| UniProt ID | Q08J02 |
| NCBI Gene ID | 54888 |
| Ensembl ID | ENSG00000012061 |
| GeneCards | NSUN2 |
| Human Protein Atlas | NSUN2 |
| Neuronal Development | NSUN2 is highly expressed in neural progenitor cells during embryonic development, where it regulates neural stem cell proliferation and differentiation[@leong2019]. |
| Synaptic Function | NSUN2-mediated tRNA modifications are essential for local protein synthesis at synapses, a process critical for synaptic plasticity and memory formation. |
| Axon Guidance | The enzyme participates in axon pathfinding through regulation of translation in growth cones. |
| Associated Diseases | neurodegeneration |
| Interactions | AGO2, ALYREF, CANCER, CTGF, ELAVL1, MMP2 |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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