gene 828 words KG: USF1
Contents

USF1 — Upstream Transcription Factor 1

🧬 Gene Info
Gene SymbolUSF1
Full NameUpstream Stimulatory Factor 1
AliasesUpstream Transcription Factor 1
Chromosome1q22
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight36 kDa
Amino Acids310 aa
Gene TypeProtein coding
UniProt IDP22415
NCBI Gene ID7399
Ensembl IDENSG00000158710
OMIM191323
GeneCardsUSF1
Human Protein AtlasUSF1
Associated DiseasesAls, Ataxia, Dystonia, Huntington, Ms, Parkinson
InteractionsUSP14
KG Connections16 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Parkinson Basal Ganglia Circuit
circuit · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: upregulates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with
ATF2 — Activating Transcription Factor 2
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MYC associated_with USF1
ATF2 associated_with USF1
YY1 associated_with USF1
USF1 promotes EndMT
USF1 activates USP14
HUNTINGTON'S DISEASE associated_with USF1
USF1 associated_with HUNTINGTON
USF1 associated_with DNA
USF1 associated_with Dystonia
USF1 associated_with Huntington

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