| Gene Symbol | TPH2 |
| Full Name | Tryptophan Hydroxylase 2 |
| Chromosome | 12q15 |
| Protein Type | Enzyme |
| Function | Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of serotonin (5-hydroxytryptamine or 5-HT) in the central nervous system. |
| Primary Expression | peripheral tissues, TPH2 is specifically expressed in neuronal cells of the raphe nuclei and other brain regions |
| Pathways | Mapk, Oxidative Stress |
| UniProt ID | Q8IWU6 |
| NCBI Gene ID | 121556 |
| Ensembl ID | ENSG00000139287 |
| OMIM | 607478 |
| GeneCards | TPH2 |
| Human Protein Atlas | TPH2 |
| Associated Diseases | Als, Bipolar, Depression, Ms, multiple sclerosis |
| Interactions | APP, Aβ, Bdnf, BDNF, DEPRESSION, GBA |
| KG Connections | 146 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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