| Gene Symbol | TMEM175 |
| Protein Type | Protein |
| Function | is a lysosomal potassium channel that plays critical roles in neuronal function and survival. |
| Subcellular Localization | lysosomes and late endosomes[@gomezsuaga2019]. The channel maintains lysosomal membrane potential, which is essential fo |
| Amino Acids | 522 aa |
| Pathways | Lysosomal pH Homeostasis |
| UniProt ID | Search UniProt |
| GeneCards | TMEM175 |
| Human Protein Atlas | TMEM175 |
| Lysosomal acidification | Proper function of lysosomal hydrolases requires an acidic interior |
| Calcium homeostasis | Indirectly affects calcium signaling through lysosomal function |
| Mitochondrial quality control | Supports mitophagy and mitochondrial dynamics |
| Dementia with Lewy Bodies (DLB) | Risk variant associated with Lewy body pathology |
| Associated Diseases | Als, Ms, Neurodegeneration, Parkinson, Parkinson's Disease |
| Interactions | AKT, ALS, AUTOPHAGY, CHCHD10, FUS, GBA |
| KG Connections | 120 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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