gene 671 words KG: TFAP4
Contents

TFAP4 — Transcription Factor AP-4

🧬 Gene Info
Gene SymbolTFAP4
Full NameTranscription Factor AP-4
Chromosome16p13.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionCerebral cortex, Hippocampus, Cerebellum, Widespread
Molecular Weight71 kDa
Amino Acids641 aa
UniProt IDQ01658
NCBI Gene ID7023
Ensembl IDENSG00000130247
OMIM601681
GeneCardsTFAP4
Human Protein AtlasTFAP4
Basic DNA-binding domainRecognizes the CAGTGT consensus sequence
Leucine zipper dimerization domainEnables homodimer and heterodimer formation with other bZIP proteins
Associated Diseasesneurodegeneration
KG Connections10 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.63
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
Genes
index · KG edge: therapeutic_target
FGFR3 - Fibroblast Growth Factor Receptor 3
gene · KG edge: associated_with
HIF1A Gene - Hypoxia Inducible Factor 1 Subunit Alpha
gene · KG edge: associated_with
NOX4 Gene
gene · KG edge: associated_with

Knowledge Graph (10 edges)

FGFR3 associated_with TFAP4
NOX4 associated_with TFAP4
TCF7L2 associated_with TFAP4
HIF1A associated_with TFAP4
GENES therapeutic_target TFAP4
AGING therapeutic_target TFAP4
TFAP4 therapeutic_target Coronary Artery Disease
TFAP4 therapeutic_target Longevity
TFAP4 therapeutic_target Aging
TFAP4 therapeutic_target Cardiovascular

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