gene 963 words KG: SNRNP70
Contents

SNRNP70 Gene

🧬 Gene Info
Gene SymbolSNRNP70
Full NameSmall nuclear ribonucleoprotein 70kDa
Chromosome19q13.33
FunctionSNRNP70 (U1-70K, RNPU1L) is a core component of the U1 small nuclear ribonucleoprotein (snRNP) complex, which plays an essential role in pre-mRNA splicing
Molecular Weight70kDa
UniProt ID[P08621](https://www.uniprot.org/uniprot/P08621)
Ensembl IDENSG00000106462
GeneCardsSNRNP70
Human Protein AtlasSNRNP70
Early RecognitionThe U1 snRNP recognizes the 5' splice site before the 3' splice site is recognized.
Cross-intron RecognitionSNRNP70 helps bridge the 5' and 3' splice sites together.
CatalysisThe assembled spliceosome catalyzes two transesterification reactions to remove introns.
RecyclingSNRNP70 is released and recycled for new splicing events.
Associated DiseasesAD, ALI, Als, Alzheimer, Alzheimer's disease, disease
InteractionsAMYLOID, AND, DNA, NTN1, NTN3, Proteins
KG Connections55 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (19)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: interacts_with
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: expressed_in
BAD Gene - BCL2-Associated Agonist of Cell Death
gene · KG edge: expressed_in
JUN Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TARDBP interacts_with SNRNP70
NTN1 interacts_with SNRNP70
SNRNP70 expressed_in JUN
SNRNP70 interacts_with NTN3
SNRNP70 interacts_with TARDBP
JUN associated_with SNRNP70
NTN3 interacts_with SNRNP70
JUN expressed_in SNRNP70
SNRNP70 interacts_with TAU
SNRNP70 associated_with TREM2

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