gene 1,892 words KG: SLC6A4
Contents

SLC6A4 Gene — Serotonin Transporter

🧬 Gene Info
Gene SymbolSLC6A4 (SERT, 5HTT)
AliasesSerotonin Transporter
Chromosome17q11.2
Functionis a membrane protein that mediates the reuptake of serotonin (5-hydroxytryptamine, 5-HT) from the synaptic cleft back into presynaptic neurons.
Molecular Weight63 kDa
Amino Acids630 aa
Exons14
PathwaysApoptosis, Epigenetic, Mapk, autophagy pathway
UniProt IDP31645
NCBI Gene ID6532
Ensembl IDENSG00000108576
Associated DiseasesAddiction, Als, Alzheimer, Alzheimer's disease
InteractionsActin, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, APOPTOSIS
KG Connections328 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (22)

APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Noradrenergic-Tau Propagation Blockade
Score: 0.71
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: associated_with
ADRA2A Gene
gene · KG edge: associated_with
ADRB2 Gene
gene · KG edge: associated_with
AKT1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SLC6A4 associated_with TRD
MAOB associated_with SLC6A4
GABRA1 associated_with SLC6A4
CHAT associated_with SLC6A4
HMGCR associated_with SLC6A4
OPRM1 associated_with SLC6A4
SLC30A8 associated_with SLC6A4
COMT associated_with SLC6A4
NBEA associated_with SLC6A4
HTR2C associated_with SLC6A4

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