gene 2,575 words KG: SCRIB
Contents

SCRIB Gene

🧬 Gene Info
Gene SymbolSCRIB
Full NameScribble Planar Cell Polarity Protein
AliasesScribble
Chromosome8q24.3
Functionencodes a protein of 1,757 amino acids with a molecular weight of approximately 220 kDa.
Primary ExpressionBrain (cortex, hippocampus, cerebellum), epithelial tissues
Molecular Weight220 kDa
Amino Acids1757 aa
Exons34
PathwaysAutophagy, Inflammasome, Phagocytosis
UniProt IDQ14160
NCBI Gene ID23513
Ensembl IDENSG00000103067
OMIM607584
GeneCardsSCRIB
Human Protein AtlasSCRIB
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsAUTOPHAGY, MICROGLIA, NEURON, NLRP3, PARKINSON, ROS
KG Connections37 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (114)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Glycosaminoglycan Template Disruption Approach
Score: 0.60
Netrin-1 Gradient Restoration
Score: 0.59
VCP-Mediated Autophagy Enhancement
Score: 0.59
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
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Related Analyses (29)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (15)

Microglia
cell · KG edge: activates
Parkinson Basal Ganglia Circuit
circuit · KG edge: activates
NeuRon Therapeutics
company · KG edge: activates
Neurodegeneration
disease · KG edge: implicated_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: co_discussed

Knowledge Graph (12 edges)

BAK1 co_discussed SCRIB
BAX co_discussed SCRIB
BID co_discussed SCRIB
MTOR co_discussed SCRIB
BDNF co_discussed SCRIB
FGF21 co_discussed SCRIB
HEPSIN co_discussed SCRIB
SCRIB co_discussed STING
APC co_discussed SCRIB
APP co_discussed SCRIB

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