gene 2,575 words KG: SCRIB
Contents

SCRIB Gene

🧬 Gene Info
Gene SymbolSCRIB
Full NameScribble Planar Cell Polarity Protein
AliasesScribble
Chromosome8q24.3
Functionencodes a protein of 1,757 amino acids with a molecular weight of approximately 220 kDa.
Primary ExpressionBrain (cortex, hippocampus, cerebellum), epithelial tissues
Molecular Weight220 kDa
Amino Acids1757 aa
Exons34
PathwaysAutophagy, Inflammasome, Phagocytosis
UniProt IDQ14160
NCBI Gene ID23513
Ensembl IDENSG00000103067
OMIM607584
GeneCardsSCRIB
Human Protein AtlasSCRIB
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsAUTOPHAGY, MICROGLIA, NEURON, NLRP3, PARKINSON, ROS
KG Connections37 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (114)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.92
CYP46A1 Overexpression Gene Therapy
Score: 0.92
SASP-Mediated Complement Cascade Amplification
Score: 0.91
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.85
APOE-Dependent Autophagy Restoration
Score: 0.85
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
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Related Analyses (29)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (15)

Microglia
cell · KG edge: activates
Parkinson Basal Ganglia Circuit
circuit · KG edge: activates
NeuRon Therapeutics
company · KG edge: activates
Neurodegeneration
disease · KG edge: implicated_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: co_discussed

Knowledge Graph (12 edges)

BAK1 co_discussed SCRIB
BAX co_discussed SCRIB
BID co_discussed SCRIB
MTOR co_discussed SCRIB
BDNF co_discussed SCRIB
FGF21 co_discussed SCRIB
HEPSIN co_discussed SCRIB
SCRIB co_discussed STING
APC co_discussed SCRIB
APP co_discussed SCRIB

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