protein 1,933 words KG: HEPSIN
Contents

Hepsin Protein

🔬 Protein Info
Gene SymbolHEPSIN
Chromosome19q13.12
Protein TypeProtease
Functionis a type II transmembrane serine protease (TTSP) that belongs to the family of trypsin-like serine proteases.
Primary Expressionvarious tissues, including the liver, kidney, and brain, where it plays important roles in extracellular matrix remodeling, cell growth, and signal tr
Amino Acids18 aa
GeneCardsHEPSIN
Human Protein AtlasHEPSIN
Associated Diseasesneurodegeneration
KG Connections102 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (26)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.95
Transcriptional Autophagy-Lysosome Coupling
Score: 0.90
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.87
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Microbial Inflammasome Priming Prevention
Score: 0.65
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Lysosomal Membrane Repair Enhancement
Score: 0.54
APOE-Dependent Autophagy Restoration
Score: 0.86
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Autophagosome Maturation Checkpoint Control
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
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Related Analyses (20)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (4)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation
exploratory · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism an
validation · proposed · Score: 0.40

See Also (15)

Endosomal-Lysosomal Pathway in Neurodegeneration
mechanism · Pages share 8 hypotheses
Neural Circuit Disruption in Neurodegeneration
mechanism · Pages share 8 hypotheses
Convergent Pathways in Neurodegeneration
mechanism · Pages share 8 hypotheses
Dystrophic Neurites in Neurodegeneration
mechanism · Pages share 8 hypotheses
HMGB1 Signaling in Neurodegeneration
mechanism · Pages share 8 hypotheses

Knowledge Graph (12 edges)

BDNF co_discussed HEPSIN
FGF21 co_discussed HEPSIN
HEPSIN co_discussed SCRIB
HEPSIN co_discussed STING
ABCD3 co_discussed HEPSIN
MYOT co_discussed HEPSIN
AMBRA1 co_discussed HEPSIN
UBIQUITIN co_discussed HEPSIN
RELA co_discussed HEPSIN
ATM co_discussed HEPSIN

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